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TranscriptomicsTranscription profiling of spinal cords from nmd mice tranplanted with ALDHhiSSClo neural stem cells to study molecular mechanism of delayed SMARD1 disease progression induced by the transplantation.
SMARD1 is an infantile autosomal recessive motor neuron (MN) disease, caused by mutations in the Immunoglobulin mu binding protein 2 (IGHMBP2). We investigated the potential of a spinal cord neural stem cell population isolated on the basis of aldehyde dehydrogenase activity (ALDH) to modify disease...
ORGANISM(S): Mus musculus 
2007-09-07 | E-GEOD-3075 | biostudies-arrayexpress
TranscriptomicsRNAi knock down of known nonsense-mediated mRNA decay (NMD) factors in Drosophila cells
All eukaryotes studied to date have the capacity to detect and degrade mRNAs harboring premature translation termination codons (PTCs) in a process called nonsense-mediated mRNA decay (NMD) (reviewed in Wagner E & Lykke-Andersen J, 2002). This surveillance system allows the cell to prevent the expre...
ORGANISM(S): Drosophila melanogaster 
2005-11-01 | E-MEXP-202 | biostudies-arrayexpress
GenomicsCRISPR screen for NMD regulators
CRISPR screen for NMD regulators
PRJNA602918 | ENA
TranscriptomicsGenome-wide consequences of compromised NMD and their relavence for variable clinical phenotype of patients with UPF3B mutations [RNA-seq]
Nonsense-mediated mRNA decay (NMD) surveillance pathways are best known to be involved in the degradation of mRNA with premature termination codons (PTCs). More recent studies demonstrate that the role of NMD pathways goes well beyond the degradation of PTC containing mRNA, into the regulation of ce...
ORGANISM(S): Homo sapiens 
2011-11-01 | E-GEOD-27199 | biostudies-arrayexpress
TranscriptomicsRNAi knockdown of NMD in D Melanogaster
Two core factors of the NMD machinery in D. melanogaster, Upf1 and Upf2, were knocked down using RNAi, as described in Rehwinkel et al. (2005) RNA, PMID: 16199763. Each of the two knockdowns were compared to mock RNAi knockdowns as described in Blanchette et al. (2005) Genes Dev, PMID: 15937219 in a...
ORGANISM(S): Drosophila melanogaster 
2010-05-18 | E-GEOD-13532 | biostudies-arrayexpress
GenomicsIdentification of NMD regulated genes in Nicotiana benthamiana
Identification of NMD regulated genes in Nicotiana benthamiana
PRJNA429737 | ENA
ProteomicsNMD-GPS_NME-058_Quadriceps_triplicate_DIA
Untargeted LC-MSMS proteomics from muscle biopsy of index patient NME-058 of the NMD-GPS cohort.
ORGANISM(S): Homo sapiens (Human) 
2026-06-15 | PXD065567 | Pride
Human Lc-msms Muscle Dia Nmd-gps 
GenomicsSEC13 functions in the NMD pathway and together with core NMD factors regulates the unfolded protein response
SEC13 functions in the NMD pathway and together with core NMD factors regulates the unfolded protein response
PRJNA1459306 | ENA
ProteomicsTranslational repression of NMD targets by GIGYF2 and EIF4E2
Translation of messenger RNAs (mRNAs) with premature translation termination codons produces truncated proteins with potentially deleterious effects. This is prevented by nonsense-mediated mRNA decay (NMD) of these mRNAs. NMD is triggered by ribosomes terminating upstream of a splice site marked by ...
ORGANISM(S): Homo sapiens (Human) 
2021-10-12 | PXD027479 | Pride
Nmd Eif4e2 Gigyf2 Translation 
TranscriptomicsNanopore sequencing reveals endogenous NMD-targeted isoforms in human cells
Nonsense-mediated mRNA decay (NMD) is a eukaryotic, translation-dependent degradation pathway that targets mRNAs with premature termination codons and also regulates the expression of some mRNAs that encode full-length proteins. Although many genes express NMD-sensitive transcripts, identifying them...
2021-07-20 | E-MTAB-10452 | biostudies-arrayexpress
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