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ProteomicsUncovering Global Non-Covalent SUMO Binder Networks Reveals that Sumoylation enhances XRCC4 activitythe stabilization of the classical Non Homologous End Joining complex.
In contrast to our extensive knowledge on covalent SUMO target proteins, we are limited in our understanding of proteins that bind SUMO family members in a non-covalent manner. We have identified interactors of different SUMO isoforms: monomeric SUMO1, monomeric SUMO2 or linear trimeric SUMO2 chains...
ORGANISM(S): Homo sapiens (Human) 
2021-01-29 | PXD022924 | Pride
Non homologous end joining Sumo Xrcc4 Proteomics 
ProteomicsZinc finger protein ZNF384 is an adaptor of KU to DNA during classical non-homologous end-joining
DNA double-strand breaks (DSBs) are among the most deleterious types of DNA damages as they can lead to mutations and chromosomal rearrangements, which underlie cancer development and progression. Non-homologous end-joining (NHEJ) is the dominant pathway for the repair of DSBs in human cells, which ...
ORGANISM(S): Homo sapiens (Human) 
2021-11-15 | PXD020417 | Pride
Non homologous end joining  double strand break repair 
GenomicsTranscriptome changes of Hela cells with blocking classical and alternative non-homologous end-joining (NHEJ) pathways
Transcriptome changes of Hela cells with blocking classical and alternative non-homologous end-joining (NHEJ) pathways
PRJNA558142 | ENA
GenomicsDNA methylation is stable after MMEJ and NHEJ double strand break repair
DNA double strand breaks (DSBs) are a major source of mutations. Both non-homologous-end-joining (NHEJ) and microhomology-mediated-end-joining (MMEJ) DSB repair pathways are error prone and produce deletions, which can lead to cancer. DSBs also lead to epigenetic changes, including demethylation, wh...
ORGANISM(S): Homo sapiens 
2022-09-11 | E-MTAB-12037 | biostudies-arrayexpress
TranscriptomicsTranscriptome changes of Hela cells with blocking classical and alternative non-homologous end-joining (NHEJ) pathways
Purpose: The recombinant endonucleases introduce double-strand breaks (DSBs) in genomic DNA at targeted sites and non-homologous end-joining (NHEJ) pathways repair the breaks introducing indels into the genome. To investigate whether there is another NHEJ pathway or if A-NHEJ and C-NHEJ are redundan...
ORGANISM(S): Homo sapiens 
2020-12-31 | GSE135274 | GEO
GenomicsDNA Methylation is stable after MMEJ and NHEJ double strand break repair - OCI-AML3 dataset
DNA double strand breaks (DSBs) are a major source of mutations. Both non-homologous-end-joining (NHEJ) and microhomology-mediated-end-joining (MMEJ) DSB repair pathways are error prone and produce deletions, which can lead to cancer. DSBs also lead to epigenetic changes, including demethylation, wh...
ORGANISM(S): Homo sapiens 
2022-08-25 | E-MTAB-12061 | biostudies-arrayexpress
ProteomicsATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks
Mutations in the ATM tumor suppressor gene confer cellular hypersensitivity to various DNA-damaging chemotherapeutic agents. To explore genetic resistance mechanisms towards such drugs, we performed genome-wide CRISPR-Cas9 loss-of-function screens in cells treated with the DNA topoisomerase I poison...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD011108 | Pride
Atm Dna damage response 
ProteomicsThe Conserved Tpk1 Regulates Non-Homologous End Joining Double-Strand Break Repair by Phosphorylation of Nej1, a Homolog of the Human XLF
The yeast cyclic-AMP dependent protein kinase A (PKA) is a ubiquitous serine-threonine kinase, encompassing three catalytic (Tpk1-3) and one regulatory (Bcy1) subunits. Evidence suggests PKA involvement in DNA damage checkpoint response, but how DNA repair pathways are regulated by PKA subunits rema...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-09-10 | PXD024695 | Pride
Genomic instability Prkacb Nhej Tpk1 Dsb repair Nej1 Kinase 
ProteomicsThe Conserved Tpk1 Regulates Non-Homologous End Joining Double-Strand Break Repair by Phosphorylation of Nej1, a Homolog of the Human XLF
The yeast cyclic-AMP dependent protein kinase A (PKA) is a ubiquitous serine-threonine kinase, encompassing three catalytic (Tpk1-3) and one regulatory (Bcy1) subunits. Evidence suggests PKA involvement in DNA damage checkpoint response, but how DNA repair pathways are regulated by PKA subunits rema...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2021-09-10 | PXD024768 | Pride
Genomic instability Prkacb Nhej Tpk1 Dsb repair Nej1 Kinase 
ProteomicsThe N-Myc-Responsive LncRNA MILIP Promotes Non-Homologous DNA End Joining to Alleviate Genotoxic Stress in Human Neuroblastoma
lncRNAMILIP promotes the NHEJ pathway through facilitating Ku70-Ku80 heterodimerization and is involved in the resistance to DNA-damaging therapeutics in neuroblastoma cells.
ORGANISM(S): Homo Sapiens 
2022-04-22 | PXD033372 |
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