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ProteomicsUncovering Global Non-Covalent SUMO Binder Networks Reveals that Sumoylation enhances XRCC4 activitythe stabilization of the classical Non Homologous End Joining complex.
In contrast to our extensive knowledge on covalent SUMO target proteins, we are limited in our understanding of proteins that bind SUMO family members in a non-covalent manner. We have identified interactors of different SUMO isoforms: monomeric SUMO1, monomeric SUMO2 or linear trimeric SUMO2 chains...
ORGANISM(S): Homo sapiens (Human) 
2021-01-29 | PXD022924 | Pride
Non homologous end joining Sumo Xrcc4 Proteomics 
UnknownDNA Ligase IV regulates XRCC4 nuclear localization.
Not available
S-EPMC4151352 | biostudies-literature
UnknownXRCC4 protein interactions with XRCC4-like factor (XLF) create an extended grooved scaffold for DNA ligation and double strand break repair.
Not available
S-EPMC3173232 | biostudies-literature
UnknownA human XRCC4-XLF complex bridges DNA.
Not available
S-EPMC3287209 | biostudies-literature
UnknownXLF regulates filament architecture of the XRCC4·ligase IV complex.
Not available
S-EPMC3008546 | biostudies-literature
UnknownFeline XRCC4 undergoes rapid Ku-dependent recruitment to DNA damage sites.
Not available
S-EPMC8972062 | biostudies-literature
ProteomicsPAXX and its paralogues synergistically direct DNA polymerase I activity in DNA repair
In this study, we characterised the interactomes of PAXX and its paralogs, XLF and XRCC4, to show that these factors share the ability to interact with DNA polymerase lambda (Poll), stimulate its activityand are required for the recruitment of Poll to laser-induced DNA damage sites.
ORGANISM(S): Homo sapiens (Human) 
2018-09-24 | PXD010891 | Pride
Polymerase lambda Xrcc4 Double strand breaks Nhej Paxx Dna repair Xlf Dna-pkcs 
UnknownRole for DNA repair factor XRCC4 in immunoglobulin class switch recombination.
Not available
S-EPMC2118634 | biostudies-literature
UnknownStructural and functional characterization of the PNKP-XRCC4-LigIV DNA repair complex.
Not available
S-EPMC5449630 | biostudies-literature
UnknownCloning, localization and focus formation at DNA damage sites of canine XRCC4.
Not available
S-EPMC5240766 | biostudies-literature
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