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TranscriptomicsThe PAXX and XLF DNA Repair Factors are Functionally Redundant in Joining DNA breaks in a G1-arrested Progenitor B Cell Line
Classical non-homologous end-joining (C-NHEJ) is a major mammalian DNA double strand break (DSB) repair pathway. Core C-NHEJ factors, such as XRCC4, are required for joining DSB intermediates of the G1 phase-specific V(D)J recombination reaction in progenitor lymphocytes. Core factors also contrib...
ORGANISM(S): Mus musculus 
2016-08-19 | E-GEOD-84102 | biostudies-arrayexpress
UnknownKu recruits XLF to DNA double-strand breaks.
Not available
S-EPMC2246615 | biostudies-literature
UnknownA human XRCC4-XLF complex bridges DNA.
Not available
S-EPMC3287209 | biostudies-literature
ProteomicsPAXX and its paralogues synergistically direct DNA polymerase I activity in DNA repair
In this study, we characterised the interactomes of PAXX and its paralogs, XLF and XRCC4, to show that these factors share the ability to interact with DNA polymerase lambda (Poll), stimulate its activityand are required for the recruitment of Poll to laser-induced DNA damage sites.
ORGANISM(S): Homo sapiens (Human) 
2018-09-24 | PXD010891 | Pride
Polymerase lambda Xrcc4 Double strand breaks Nhej Paxx Dna repair Xlf Dna-pkcs 
UnknownXLF-mediated NHEJ activity in hepatocellular carcinoma therapy resistance.
Not available
S-EPMC5437682 | biostudies-literature
GenomicsPhosphorylation of DNA-PKcs at the S2056 cluster ensures efficient and productive lymphocyte development in XLF-deficient mice
Phosphorylation of DNA-PKcs at the S2056 cluster ensures efficient and productive lymphocyte development in XLF-deficient mice
PRJNA951734 | ENA
UnknownXLF and H2AX function in series to promote replication fork stability.
Not available
S-EPMC6605786 | biostudies-literature
UnknownA role for XLF in DNA repair and recombination in human somatic cells.
Not available
S-EPMC3948327 | biostudies-literature
UnknownXLF regulates filament architecture of the XRCC4·ligase IV complex.
Not available
S-EPMC3008546 | biostudies-literature
UnknownSynthetic lethality between PAXX and XLF in mammalian development.
Not available
S-EPMC5088564 | biostudies-literature
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