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ProteomicsPAXX and its paralogues synergistically direct DNA polymerase I activity in DNA repair
In this study, we characterised the interactomes of PAXX and its paralogs, XLF and XRCC4, to show that these factors share the ability to interact with DNA polymerase lambda (Poll), stimulate its activityand are required for the recruitment of Poll to laser-induced DNA damage sites.
ORGANISM(S): Homo sapiens (Human) 
2018-09-24 | PXD010891 | Pride
Polymerase lambda Xrcc4 Double strand breaks Nhej Paxx Dna repair Xlf Dna-pkcs 
ProteomicsPAXX is an accessory c-NHEJ factor that associates with Ku70 and has overlapping functions with XLF
In mammalian cells, classical non-homologous end joining (c-NHEJ) is critical for DNA double-strand break repair induced by ionizing radiation and during V(D)J recombination in developing B and T lymphocytes. Recently, PAXX was identified as a new c-NHEJ core component. We report here, that PAXX-def...
ORGANISM(S): Homo sapiens (Human) 
2016-10-06 | PXD004659 | Pride
Non-homologous end joining Micro-homology mediated end joining V(d)j recombination Genomic instability Dna double-strand break 
GenomicsTranscriptome profiling of PAXX knockdown in HCT116 colorectal cancer cells
Transcriptome profiling of PAXX knockdown in HCT116 colorectal cancer cells
PRJNA1526769 | ENA
TranscriptomicsTranscriptome profiling of PAXX knockdown in HCT116 colorectal cancer cells
To investigate the transcriptional changes induced by PAXX depletion in colorectal cancer cells, bulk RNA sequencing was performed in HCT116 cells transfected with PAXX-targeting siRNA or negative-control siRNA. Three independent biological replicates were analyzed for each group.
ORGANISM(S): Homo sapiens 
2026-09-15 | GSE346887 | GEO
UnknownSynthetic lethality between PAXX and XLF in mammalian development.
Not available
S-EPMC5088564 | biostudies-literature
UnknownDistinct functions of PAXX and MRI during chromosomal end joining.
Not available
S-EPMC12179622 | biostudies-literature
UnknownDistinct functions of PAXX and MRI during chromosomal end joining.
Not available
S-EPMC11370355 | biostudies-literature
UnknownPAXX binding to the NHEJ machinery explains functional redundancy with XLF.
Not available
S-EPMC10413649 | biostudies-literature
UnknownSpecific Roles of XRCC4 Paralogs PAXX and XLF during V(D)J Recombination.
Not available
S-EPMC5033762 | biostudies-literature
UnknownPAXX and its paralogs synergistically direct DNA polymerase λ activity in DNA repair.
Not available
S-EPMC6155126 | biostudies-literature
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