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MetabolomicsLyso-lipid induced oligodendrocytes maturation underlie restoration of optic nerve function
Not available
ORGANISM(S): Rattus norvegicus 
ST002047 | MetabolomicsWorkbench
GenomicsDynamic Changes in Ezh2 Gene Occupancy Underlie Its Involvement in Neural Stem Cell Self-Renewal and Differentiation towards Oligodendrocytes
BACKGROUND: The polycomb group protein Ezh2 is an epigenetic repressor of transcription originally found to prevent untimely differentiation of pluripotent embryonic stem cells. We previously demonstrated that Ezh2 is also expressed in multipotent neural stem cells (NSCs). We showed that Ezh2 expres...
ORGANISM(S): Mus musculus 
2012-07-30 | E-GEOD-31655 | biostudies-arrayexpress
ProteomicsVAMP2/3-dependent membrane proteome in oligodendrocytes
Which proteins in oligodendrocytes require VAMP2/3-mediated exocytosis for membrane trafficking? We isolated primary oligodendrocytes from transgenic mice expressing oligodendrocyte-targeted botulinum toxin and littermate controls and used surface biotinylation to determine which proteins were diffe...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-14 | PXD036174 | Pride
Myelin Oligodendrocytes 
GenomicsGenome-wide mapping of Olig2 targets in primary oligodendrocytes
Myelination by oligodendrocytes in the central nervous system (CNS) is essential for proper brain function, yet the molecular determinants that control this process remain poorly understood. The basic helix-loop-helix transcription factors Olig1 and Olig2 promote myelination, whereas bone morphogene...
ORGANISM(S): Rattus norvegicus 
2012-08-31 | E-GEOD-40506 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling of two stage specific rat oligodendrocytes
microRNA expression profiles in two stage-specific populations of oligodendrocytes: OPCs expressing the A2B5 ganglioside (A2B5+ cells) and OLs that are positive for the galactocerebroside marker (GalC+ cells). Cells were isolated postnatal day 7.
ORGANISM(S): Rattus norvegicus 
2008-11-11 | E-MEXP-1589 | biostudies-arrayexpress
ProteomicsProteome analysis of the MO3.13 cell line from human oligodendrocytes
MO3.13 is an immortal human-human hybrid cell line that express phenotypic characteristics of primary oligodendrocytes. It was created by fusing a 6-thioguanine-resistant mutant of the human rhabdomyosarcoma RD (cancer of skeletal muscle) with adult human oligodendrocytes by a lectin-enhanced polyet...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-06-12 | MSV000083971 | MassIVE
TranscriptomicsA Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes
A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function Understanding the cell-cell interactions that control CNS development and function has long been limited by the lack of methods to cleanly separate astrocytes, neu...
ORGANISM(S): Mus musculus 
2007-12-30 | E-GEOD-9566 | biostudies-arrayexpress
TranscriptomicsPKC-dependent MYRF dysregulation links Aβ pathology to oligodendrocyte, myelin and cognitive alterations in Alzheimer’s disease
Alzheimer’s disease (AD) is characterized not only by neuronal loss and synaptic dysfunction but also by emerging evidence of oligodendrocyte and myelin pathology. Amyloid-β (Aβ), a hallmark of AD, disrupts oligodendrocyte homeostasis through mechanisms that remain poorly understood. Here, we invest...
ORGANISM(S): Mus musculus 
2025-12-31 | E-MTAB-16400 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of differentiation of Rattus norvegicus oligodendrocytes from their progenitor cells
Oligodendrocytes undergo extensive changes as they differentiate from progenitors into myelinating cells. To better understand the; molecular mechanisms underlying this transformation, we performed a comparative analysis using gene expression profiling of A2B5+; oligodendrocyte progenitors and O4+ o...
ORGANISM(S): Rattus norvegicus 
2007-11-29 | E-GEOD-5940 | biostudies-arrayexpress
TranscriptomicsAfter demyelination in the adult CNS, oligodendrocyte precursor cells revert to an immature mRNA profile and express immune cues favoring their migration
In multiple sclerosis (MS) and experimental models of demyelination, myelin repair is mostly achieved by oligodendrocyte precursor cells (OPCs). To gain insight into the biological specificity of these adult precursors, in the perspective to better understand why remyelination often fails in MS, we ...
ORGANISM(S): Mus musculus 
2014-11-06 | E-GEOD-48872 | biostudies-arrayexpress
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