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ProteomicsMouse periodontal ligament tissue after orthodontic tooth movement
Mouse periodontal ligament tissue after orthodontic tooth movement for 14 days. Tissue was dissected by a laser microdissection microscope. Samples were analyzed separately at mesial (compression) and distal (tension) sides.
ORGANISM(S): Mus Musculus (mouse) 
2022-12-16 | PXD030430 | JPOST Repository
GenomicsNeutrophils Orchestrate Osteoclastogenesis in Orthodontic Tooth Movement
Neutrophils Orchestrate Osteoclastogenesis in Orthodontic Tooth Movement
PRJNA1436506 | ENA
ProteomicsImportin-7 Promotes Tension-Induced Osteogenesis by Regulating RUNX2 Nuclear Translocation during Orthodontic Tooth Movement
Orthodontic tooth movement (OTM) is primarily driven by alveolar bone remodeling, wherein tension-induced osteogenesis plays a central role. Importin7 (IPO7) has been identified as a highly mechanoresponsive nuclear transport receptor (NTR). However, its role in regulating tension-induced osteogenes...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-10-06 | PXD061760 | Pride
Runx2 Mechanotransduction Ipo7 Tooth movement Nuclear translocation Alveolar bone remodeling 
ProteomicsBone morphogenetic protein 4 in human saliva during orthodontic therapy
In orthodontic therapy periodontal tissue responds to mechanical stimuli by bone remodeling mediated by specific molecules involved in periodontal regeneration and homeostasis. The resulting changes are reflected in the salivary proteome that is emerging as a valuable diagnostic tool. We analyzed t...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD016481 | Pride
Saliva Proteomics Bmper Bone remodeling Orthodontic tooth movement Bmp4 
GenomicsMacrophage ATF6 Accelerates Orthodontic Tooth Movement through Promoting Tnfα Transcription
Macrophage ATF6 Accelerates Orthodontic Tooth Movement through Promoting Tnfα Transcription
PRJNA1031204 | ENA
GenomicsMacrophage ATF6 Accelerates Orthodontic Tooth Movement through Promoting Tnfα Transcription
Macrophage ATF6 Accelerates Orthodontic Tooth Movement through Promoting Tnfα Transcription
PRJNA1030912 | ENA
TranscriptomicsEffect of corticision on orthodontic tooth movement in a rat model as assessed by RNA sequencing
Corticision is a common technique to accelerate orthodontic tooth movement; however, not much is known about the underlying mechanisms. In this study, we investigated the mechanism of alveolar tissue remodeling after corticision in a rat model of tooth movement (TM) by analyzing the differential tra...
ORGANISM(S): Rattus norvegicus 
2018-02-13 | GSE94825 | GEO
GenomicsGene expression profile at single cell level of alveolar bone during orthodontic tooth movement
Gene expression profile at single cell level of alveolar bone during orthodontic tooth movement
PRJNA1214349 | ENA
TranscriptomicsNeutrophils Orchestrate Osteoclastogenesis in Orthodontic Tooth Movement
To elucidate the biological mechanisms of alveolar bone remodeling during orthodontic tooth movement (OTM), we performed single-cell RNA sequencing (scRNA-seq) on periodontal ligament (PDL) tissues from a mouse OTM model. We identified 11 distinct cell clusters and revealed that neutrophils are a pr...
ORGANISM(S): Mus musculus 
2026-07-10 | GSE324651 | GEO
GenomicsIdentification of candidate immunity biomarkers associated with age-related variations in osteoclast activity following orthodontic tooth movement
Identification of candidate immunity biomarkers associated with age-related variations in osteoclast activity following orthodontic tooth movement
PRJNA1273898 | ENA
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