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MetabolomicsHigh-confidence untargeted lipidomics of mammalian serum using LC-TIMS-PASEF

This study aimed to establish and validate a robust untargeted lipidomics workflow for the analysis of human serum using reversed-phase liquid chromatography coupled to trapped ion mobility spectrometry time-of-flight mass spectrometry (RP-LC-TIMS-TOF MS). Commercial pooled human serum was used a...

2026-05-26 | MTBLS14002 | MetaboLights
Proteomicsdia-PASEF analysis of human amygdala in Alzheimer’s disease
dia-PASEF analysis of human amygdala in Alzheimer’s disease
ORGANISM(S): Homo sapiens (Human) 
2023-06-28 | PXD038322 | Pride
Dia-pasef Alzheimer Human Amygdala 
GenomicsBenchmarking Software for DDA-PASEF Immunopeptidomics
Benchmarking Software for DDA-PASEF Immunopeptidomics
PRJEB98909 | ENA
ProteomicsSynchro-PASEF slices peptide precursors enabling specific fragment extraction and interference removal in data independent acquisition
Data independent acquisition methods have become increasingly popular in mass spectrometry (MS)-based proteomics because they enable parallel and continuous acquisition of fragment spectra. However, these advantages come with the challenge of correctly reconstructing the precursor-fragment relations...
ORGANISM(S): Bos taurus (Bovine) Candida albicans (Yeast) Homo sapiens (Human) Oryctolagus cuniculus (Rabbit) 
2023-03-10 | PXD037766 | Pride
Pasef Tof Rapid analysis Tims Data-independent acquisition Scan mode 
ProteomicsFour-dimensional proteomics analysis of human cerebrospinal fluid on a trapped ion mobility mass spectrometer using PASEF
A quadrupole time-of-flight mass spectrometry coupled with a trapped ion mobility mass spectrometer operated in parallel accumulation-serial fragmentation mode has recently emerged as proteome profiling platform capable of providing four dimensional features of elution time, collision cross section...
ORGANISM(S): Homo sapiens (Human) 
2023-02-28 | PXD035249 | Pride
4d proteomics And alzheimer’s disease Dda-pasef Csf Diapasef Prm-pasef 
Proteomicsprm-PASEF and g-dia-PASEF analysis of plasma samples from colorectal cancer and control patients
Quantitative analysis of 10 CRC vs 10 control human plasma samples with the prm-PASEF and g-dia-PASEF acquisition methodes
ORGANISM(S): Homo sapiens (Human) 
2023-04-11 | PXD036594 | Pride
Pasef prm dia plasma colorectal cancer 
ProteomicsA hybrid DDA/DIA-PASEF based assay library for a deep proteotyping of triple-negative breast cancer
Generation of a new library of targeted mass spectrometry assays for accurate protein quantification in triple negative breast cancer (TNBC) tissues. Primary tumor tissue lysates from 105 TNBC patients treated at Masaryk Memorial Cancer Institute (MMCI) in Brno, Czech Republic, were used to generate...
ORGANISM(S): Homo sapiens (Human) 
2024-05-31 | PXD047793 | Pride
Proteomics Mass spectrometry Data independent acquisition Assay library Triple-negative breast cancer 
ProteomicsSystematic evaluation of PASEF acquisition strategies in complex metaproteomes
Trapped ion mobility spectrometry coupled with parallel accumulation–serial fragmentation (PASEF) has enabled multiple acquisition strategies for proteomics, yet their comparative performance in complex metaproteomes remains unclear. Here we benchmark five modes—DDA-, DIA-, Slice-, Synchro- and midi...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-03 | PXD073688 | Pride
Pasef Metaproteomics 
ProteomicsRapid and ion mobility-resolved phosphoproteomics with dia-PASEF
Mass spectrometry-based phosphoproteomics has identified >150,000 post-translational phosphorylation sites in the human proteome. To disentangle their functional relevance, complex experimental designs that require increased throughput are now coming into focus. Here, we apply dia-PASEF on a trapped...
ORGANISM(S): Homo sapiens (Human) 
2022-10-26 | PXD033904 | Pride
Tims Technology Pasef Dia-pasef Phosphoproteomics Data-independent acquisition Ion mobility 
ProteomicsOnline parallel accumulation – serial fragmentation (PASEF) with a novel trapped ion mobility mass spectrometer
In bottom-up proteomics, peptides are separated by liquid chromatography with elution peak widths in the range of seconds, while mass spectra are acquired in about 100 microseconds with time-of-fight (TOF) instruments. This allows adding ion mobility as a third dimension of separation. Among several...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2018-11-06 | PXD010012 | Pride
Tims Pasef Technological 
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