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UnknownStructural analysis of Red1 as a conserved scaffold of the RNA-targeting MTREC/PAXT complex.
Not available
S-EPMC9402713 | biostudies-literature
ProteomicsAn extended PAXT connection is required for turnover of nuclear polyadenylated RNA in human cells
Recruitment of the human ribonucleolytic RNA exosome to nuclear polyadenylated (pA+) RNA is facilitated by the Poly(A) Tail eXosome Targeting (PAXT) connection. Besides its core dimer, formed by the exosome co-factor MTR4 and the ZFC3H1 protein, the PAXT connection remains poorly defined. By charact...
ORGANISM(S): Homo Sapiens (human) 
2019-10-31 | PXD016070 | JPOST Repository
GenomicsThe PAXT connection is a modifier of rare codon-enriched protein expression
The PAXT connection is a modifier of rare codon-enriched protein expression
PRJNA1224441 | ENA
ProteomicsMechanistic insights into RNA surveillance by the canonical poly(A) polymerase Pla1 of the MTREC complex
The S. pombe orthologue of the human PAXT complex, Mtl1-Red1 Core (MTREC), is an eleven-subunit complex which targets cryptic unstable transcripts (CUTs) to the nuclear RNA exosome for degradation. It encompasses the canonical poly(A) polymerase Pla1, responsible for polyadenylation of nascent RNA t...
ORGANISM(S): Fungi Schizosaccharomyces pombe SPK1820 
2022-12-01 | PXD035413 | Pride
Mtrec complex  s. pombe  paxt complex  rna surveilance 
TranscriptomicsThe PAXT connection is a modifier of rare codon-enriched protein expression
Synonymous codons occur at unequal rates in the coding genome, with those represented least often termed ‘rare.’ Rare codon-enriched genes typically exhibit poor expression due to reduced transcription, mRNA stability, export, and translation. However, there are an increasing number of examples wher...
ORGANISM(S): Homo sapiens 
2026-08-24 | GSE289748 | GEO
ProteomicsDual agonistic and antagonistic roles of ZC3H18 provides for co-activation of distinct nuclear RNA decay pathways
The RNA exosome is a versatile ribonuclease. In the nucleoplasm of mammalian cells, it is assisted by its adaptors the Nuclear EXosome Targeting (NEXT) complex and the PolyA eXosome Targeting (PAXT) connection. Via its association with the ARS2 and ZC3H18 proteins, NEXT/exosome is recruited to cappe...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD045842 | Pride
Ars2 Nuclear rna decay Next Paxt Activation Zc3h18 Inhibition 
TranscriptomicsThe fission yeast MTREC complex targets CUTs and unspliced mRNAs to the nuclear exosome [RIP-ChIP]
Cryptic unstable transcripts (CUTs) are rapidly degraded by the nuclear exosome, however, the way they are recognized and targeted to the exosome is not fully understood. The recently identified Schizosaccharomyces pombe MTREC complex has been shown to promote degradation of meiotic mRNAs and regula...
ORGANISM(S): Schizosaccharomyces pombe 
2015-05-22 | E-GEOD-64980 | biostudies-arrayexpress
TranscriptomicsThe fission yeast MTREC complex targets CUTs and unspliced mRNAs to the nuclear exosome [expression array]
Cryptic unstable transcripts (CUTs) are rapidly degraded by the nuclear exosome, however, the way they are recognized and targeted to the exosome is not fully understood. The recently identified Schizosaccharomyces pombe MTREC complex has been shown to promote degradation of meiotic mRNAs and regula...
ORGANISM(S): Schizosaccharomyces pombe 
2015-05-22 | E-GEOD-64979 | biostudies-arrayexpress
GenomicsA functional link between nuclear RNA decay and transcritional control mediated by the Polycomb Repressive Complex 2
Pluripotent embryonic stem (ES) cells constitute an essential cellular niche in animal development. It is well documented that ES cells are sustained by epigenetic and transcriptional regulation, but the role of post-transcriptional processes remains less explored. Here, we identify a link between n...
ORGANISM(S): Mus musculus 
2019-11-12 | GSE137491 | GEO
TranscriptomicsThe fission yeast MTREC complex targets CUTs and unspliced mRNAs to the nuclear exosome [RNA-Seq]
Cryptic unstable transcripts (CUTs) are rapidly degraded by the nuclear exosome, however, the way they are recognized and targeted to the exosome is not fully understood. The recently identified Schizosaccharomyces pombe MTREC complex has been shown to promote degradation of meiotic mRNAs and regula...
ORGANISM(S): Schizosaccharomyces pombe 
2015-05-22 | E-GEOD-64991 | biostudies-arrayexpress
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