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ProteomicsDual agonistic and antagonistic roles of ZC3H18 provides for co-activation of distinct nuclear RNA decay pathways
The RNA exosome is a versatile ribonuclease. In the nucleoplasm of mammalian cells, it is assisted by its adaptors the Nuclear EXosome Targeting (NEXT) complex and the PolyA eXosome Targeting (PAXT) connection. Via its association with the ARS2 and ZC3H18 proteins, NEXT/exosome is recruited to cappe...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD045842 | Pride
Ars2 Nuclear rna decay Next Paxt Activation Zc3h18 Inhibition 
GenomicsThe early RNA decay factor ZC3H18 directs first intron splicing
The early RNA decay factor ZC3H18 directs first intron splicing
PRJNA1365877 | ENA
GenomicsRNA-seq analysis of control and ZC3H18-depleted ovarian cancer cells
RNA-seq analysis of control and ZC3H18-depleted ovarian cancer cells
PRJNA562626 | ENA
UnknownZC3H18 regulates alternative splicing and related genes in cervical cancer.
Not available
S-EPMC12454084 | biostudies-literature
UnknownZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer.
Not available
S-EPMC6789141 | biostudies-literature
TranscriptomicsThe early RNA decay factor ZC3H18 directs first intron splicing
The splicing of pre-mRNA into mature mRNA is essential for proper gene expression. For multi-intronic transcripts, the Cap Binding Complex (CBC) has long been recognized as a critical facilitator of 1st intron splicing1–4, yet the underlying molecular mechanism remains elusive. The CBC is also invol...
ORGANISM(S): Homo sapiens 
2026-09-29 | GSE310395 | GEO
GenomicsRNA-seq analysis of differentially expressed genes between WT and KD ZC3H18 KYSE150/ECA109 cells.
RNA-seq analysis of differentially expressed genes between WT and KD ZC3H18 KYSE150/ECA109 cells.
PRJNA1226578 | ENA
UnknownZinc finger protein ZC3H18 is abnormally expressed in esophageal cancer tissues and facilitates the proliferation of esophageal cancer cells.
Not available
S-EPMC11894379 | biostudies-literature
UnknownCharacterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.
Not available
S-EPMC5770337 | biostudies-literature
UnknownDual agonistic and antagonistic roles of ZC3H18 provide for co-activation of distinct nuclear RNA decay pathways.
Not available
S-EPMC10720265 | biostudies-literature
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