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GenomicsGenome-wide map of GATA6 DNA binding in human PDAC cells
By studying a mouse model, as well as human tumors samples and cell lines, we have revealed a tumor suppressive role for Gata6 in the pathogenesis of pancreatic ductal adenocarcinoma (PDAC). In order to understand the mechanism underlying such tumor suppressive function, we analyzed the genome-wide ...
ORGANISM(S): Homo sapiens 
2015-02-03 | E-GEOD-47535 | biostudies-arrayexpress
ProteomicsAnalysis of Global Protein Expression in PIWIL1 knockdown PDAC cell line
In contrast to the great advances in understanding of the functions of Piwi in germlines, their actions in cancer cells remain less clear. In particular, Piwi proteins have been asserted as oncoproteins, but little is known about how their oncogenic function is achieved in cancer cells. We conducted...
ORGANISM(S): Homo sapiens (Human) 
2020-02-18 | PXD017452 | Pride
Human Piwil1 Pdac 
Transcriptomics3' mRNA-seq of human Ma-Mel-47 (melanoma) and Panc89 (PDAC) cells treated with the USP7 degraders NK266 and NK250, respectively, for 72 h.
3' mRNA-seq was used to study the effects of USP7 degradation by the degraders NK266 and NK250 on gene expression in a human melanoma and PDAC cell line, respectively.
ORGANISM(S): Homo sapiens 
2026-03-27 | E-MTAB-16302 | biostudies-arrayexpress
ProteomicsHuman Pancreatic Ductal Adenocarcinoma (PDAC), LC-MS/MS
The aim of the study was to characterize a common molecular mechanism for paclitaxel resistance in Patu-T and Suit-2.028 PDAC cell lines. Despite the ATP-binding cassette (ABC) trasnsporters were already shown to be involved in various chemo-resistant forms of cancers but not in PDAC, the most likel...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD040930 | Pride
Human Pdac cell models Pancreas Lc-ms/ms 
TranscriptomicsExpression profiling of pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) has the worst prognosis of all common cancers, but divergent outcomes are apparent between patients. To delineate the intertumor heterogeneity that contributes to this, we aimed to identify clinically distinct gene expression-based subgroups. From a cohort of ...
ORGANISM(S): Homo sapiens 
2020-01-25 | E-MTAB-6830 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of cancer associated fibroblasts from pancreatic ductal adenocarcinoma in comparison to normal dermal fibroblasts
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive tumor type with extremely high mortality (up to 92%) during 5 years after diagnosis. Here, cancer associated fibroblasts (CAF) from PDAC were compared to CAF from melanoma metastases (MELF) and to normal dermal fibroblasts (DF). The analysis w...
ORGANISM(S): Homo sapiens 
2021-11-01 | E-MTAB-8764 | biostudies-arrayexpress
TranscriptomicsArray CGH analysis for 29 pancreatic ductal adenocarcinoma (PDAC) samples
Background/Aims: Microarray-based comparative genomic hybridisation (CGH) has allowed high-resolution analysis of DNA copy number alterations across the entire cancer genome. Recent advances in bioinformatics tools enable us to perform a robust and highly sensitive analysis of array CGH data and fac...
ORGANISM(S): Homo sapiens 
2008-12-16 | E-GEOD-9672 | biostudies-arrayexpress
TranscriptomicsCombinatorial analysis of miRNA and mRNA expression in pancreatic ductal adenocarcinoma (PDAC)_mRNA
miRNAs are known to be involved in PDAC tumorigenesis, but only a few biologically relevant gene targets have been identified. Here we show that three miRNAs (miR-21, miR-23a and miR-27a) act in concert for the cooperative suppression of several tumor suppressor genes of which we experimentally vali...
ORGANISM(S): Homo sapiens 
2013-12-30 | E-GEOD-41368 | biostudies-arrayexpress
TranscriptomicsCombinatorial analysis of miRNA and mRNA expression in pancreatic ductal adenocarcinoma (PDAC)_miRNA
miRNAs are known to be involved in PDAC tumorigenesis, but only a few biologically relevant gene targets have been identified. Here we show that three miRNAs (miR-21, miR-23a and miR-27a) act in concert for the cooperative suppression of several tumor suppressor genes of which we experimentally vali...
ORGANISM(S): Homo sapiens 
2013-12-30 | E-GEOD-41369 | biostudies-arrayexpress
ProteomicsDeep Exploration of the Immunopeptidome of a Pancreatic Cancer Cell Line Panc1: Implications for Clinical Immunopeptidomics and Immunotherapy (SWATH-DIA datasets)
Pancreatic ductal adenocarcinoma (PDAC), with its devastating prognosis and limited treatment options, necessitates innovative therapeutic strategies. T-cell-based immunotherapy has shown promise for various cancers, including PDAC. Thus, a comprehensive understanding of the HLA-peptidome in PDAC is...
ORGANISM(S): Homo sapiens (Human) 
2025-07-14 | PXD054417 | Pride
Tumor-associated antigens Hla Variable window zenoswath dia Pancreatic cancer Immunopeptidome Pdac 
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