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ProteomicsUnbiased identification of the liposome protein corona using photoaffinity based chemoproteomics
Determination of protein adsorption to the surface of a nanoparticle determined by photoaffinity based chemoproteomics.
ORGANISM(S): Homo sapiens (Human) 
2020-04-02 | PXD016229 | Pride
Chemoproteomics photoaffinity labelling human serum protein corona 
UnknownTarget Agnostic Photoaffinity Labelling by Sulfonylhydrazones.
Not available
S-EPMC12015381 | biostudies-literature
UnknownDevelopment of a Multifunctional Benzophenone Linker for Peptide Stapling and Photoaffinity Labelling.
Not available
S-EPMC4862033 | biostudies-literature
UnknownDesign and synthesis of a novel photoaffinity probe for labelling EGF receptor tyrosine kinases.
Not available
S-EPMC6009917 | biostudies-literature
UnknownA fluorescent photoaffinity probe for formyl peptide receptor 1 labelling in living cells.
Not available
S-EPMC9994102 | biostudies-literature
UnknownDesigning photoaffinity tool compounds for the investigation of the DENV NS2B-NS3 protease allosteric binding pocket.
Not available
S-EPMC10650954 | biostudies-literature
ProteomicsA biotin targeting chimera (BioTAC) system to map small molecule interactomes in situ
Understanding how small molecules bind to specific protein complexes in living cells is critical to understanding their mechanism-of-action. Unbiased chemical biology strategies for direct readout of protein interactome remodelling by small molecules would provide advantages over target-focused appr...
ORGANISM(S): Homo sapiens (Human) 
2023-12-04 | PXD041401 | Pride
Lc-msms 
ProteomicsAn 8-Mercaptoquinoline Motif Enriches Minichromosome Maintenance Complex Components as Significant Metalloprotein Targets in Live Cells
Affinity-based probes are valuable tools for detecting binding interactions between small molecules and proteins in complex biological environments. Metalloproteins are a class of therapeutically significant biomolecules which bind metal ions as part of key structural or catalytic domains and are co...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-06-28 | PXD052663 | Pride
Photoaffinity labelling Affinity-based protein profiling Metalloenzymes Affinity-based probes Metalloproteins 
ProteomicsBroad-range metalloprotease profiling in plants uncovers immunity provided by defence-related metalloenzyme
Plants encode for >100 metalloproteases representing >19 different protein families. Tools to study this large and diverse class of proteases have not yet been introduced into plant science. Here, we used hydroxamate-based photoaffinity probes to explore plant proteomes for metalloproteases. We dete...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) Nicotiana benthamiana 
2022-08-12 | PXD032265 | Pride
Photoaffinity labelling Arabidopsis Prp27 Metalloproteases Immunity 
ProteomicsProteomic Profiling of Potential E6AP Substrates via Ubiquitin-based Photo-Crosslinking Assisted Affinity Enrichment
E6AP/UBE3A, the founding member of HECT-type (Homologous to E6AP C-terminus) E3 ligases, is implicated in human papillomaviruses (HPV)-mediated cervical cancer and neurodevelopmental disorders like Angelman and Dup15q syndromes. To elucidate the function of E3 ligases, knowledge about their substrat...
ORGANISM(S): Homo sapiens (Human) 
2025-01-27 | PXD055649 | Pride
Photoaffinity labelling Proteomics Substrate identification Ubiquitination E6ap/ube3a 
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