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TranscriptomicsPolypyrimidine tract-binding protein homologues from Arabidopsis are key regulators of alternative splicing with implications in fundamental developmental processes
Alternative splicing (AS) generates transcript variants by the definition of different exonic and intronic regions and causes a massive expansion of transcriptome diversity. Changes in AS patterns have been found to be linked to manifold biological processes, yet fundamental aspects such as the regu...
ORGANISM(S): Arabidopsis thaliana 
2012-10-22 | E-GEOD-41433 | biostudies-arrayexpress
TranscriptomicsDrosophila PTB regulates dorso-ventral patterning genes in embryos
Drosophila PTB (Polypyrimidine Tract-binding protein dmPTB) regulates dorso-ventral patterning genes in embryos Comparison of wild type (yw genotype) and PTB mutant (heph03429) drosophila embryos
ORGANISM(S): Drosophila melanogaster 
2014-05-10 | E-GEOD-57517 | biostudies-arrayexpress
GenomicsPolypyrimidine Tract Binding Protein 1 regulates the activation of mouse CD8 T cells
Polypyrimidine Tract Binding Protein 1 regulates the activation of mouse CD8 T cells
PRJNA787360 | ENA
ProteomicsPolypyrimidine Tract Binding Proteins PTBP1 and PTBP2 Interact with Distinct Proteins Under Splicing Conditions
RNA binding proteins play an important role in regulating alternative pre-mRNA splicing and in turn cellular gene expression. Polypyrimidine tract binding proteins, PTBP1 and PTBP2, are paralogous RNA binding proteins that play a critical role in the process of neuronal differentiation and maturatio...
ORGANISM(S): Homo sapiens (Human) 
2022-01-20 | PXD029899 | Pride
Nptb Ptbp1 Ptbp2 Splicing Ptbp Ptb Lc-ms/ms 
TranscriptomicsInteractions of aCPs with Cytosine-rich Polypyrimidine Tracts Enhance Splicing of Cassette Exons
Alternative splicing comprises a robust generator of mammalian transcriptome complexity. Splice site specification and activity are controlled by interactions of cis-acting determinants on a transcript with specific RNA binding proteins. A major subset of these interactions comprises interactions lo...
ORGANISM(S): Homo sapiens 
2016-03-01 | E-GEOD-71569 | biostudies-arrayexpress
TranscriptomicsRegulation of Vertebrate Nervous System-Specific Alternative Splicing and Development by an SR-Related Protein
Alternative splicing is a key process underlying the evolution of increased proteomic and functional complexity and is especially prevalent in the mammalian nervous system. However, the factors and mechanisms governing nervous system-specific alternative splicing are not well understood. Through a g...
ORGANISM(S): Mus musculus 
2010-05-15 | E-GEOD-16187 | biostudies-arrayexpress
GenomicsPolypyrimidine tract binding proteins are essential for B cell development
Polypyrimidine tract binding proteins are essential for B cell development
PRJNA563911 | ENA
TranscriptomicsPTB CLIP-seq
Recent transcriptome analysis indicates that >90% of human genes undergoes alternative splicing, underscoring the contribution of differential RNA processing to diverse proteomes in higher eukaryotic cells. The polypyrimidine tract binding protein PTB is a well-characterized splicing repressor, but ...
ORGANISM(S): Homo sapiens 
2009-12-24 | E-GEOD-19323 | biostudies-arrayexpress
TranscriptomicsPolypyrimidine Tract Binding Protein 1 regulates the activation of mouse CD8 T cells
We show that the RNA-binding protein Polypyrimidine Tract Binding Protein 1 (PTBP1) is dispensable for the development of naïve mouse CD8 T cells, but is necessary for the optimal expansion and production of effector molecules by antigen-specific CD8 T cells in vivo. PTBP1 has an essential role in r...
ORGANISM(S): Mus musculus 
2021-12-09 | GSE190512 | GEO
TranscriptomicsGene Expression and Exon Splicing Change Analysis of Mouse N2A Cell Transcriptome upon Polypyrimidine tract-binding protein depletion.
Purpose : Splicing factors regulate splice site choices in pre-mRNA and determine final exon set in mRNA. To understand mechanisms of splicing regulation, it is important to identify and characterize exon targets of splicing factors. Recently, development of RNA-seq technology enables researchers to...
ORGANISM(S): Mus musculus 
2013-12-01 | E-GEOD-45119 | biostudies-arrayexpress
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