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ProteomicspSILAC method coupled with two complementary digestion approaches reveals PRPF39 as a new E7070-dependent DCAF15 substrate
In this study, we used a novel strategy of pSILAC method coupled with two complementary digestion approaches to find potential substrates of E7070, and reveals PRPF39 as E7070-dependent DCAF15 substrate.
ORGANISM(S): Homo Sapiens 
2019-10-18 | PXD015892 |
Proteomicsp53-regulated networks of protein, mRNA, miRNA and lncRNA expression revealed by integrated pSILAC and NGS analyses
We determined the effect of p53 activation on de novo protein synthesis using quantitative proteomics of newly synthesized proteins (pulsed stable isotope labeling with amino acids in cell culture, pSILAC) in combination with mRNA and non-coding RNA expression analyses by next generation sequencing ...
ORGANISM(S): Homo sapiens (Human) 
2015-07-23 | PXD001976 | Pride
Psilac Human Transcriptional network Biomarker P53 Tumor-suppressor 
ProteomicspSILAC-SP3 of RGC axonal growth cones
To form operative neuronal networks neurons connect to their synaptic partners by axonal outgrowth guided by the movement of the axon tip, a specialized structure known as the growth cone (GC), which travels along stereotypical paths by sensing extracellular guidance cues. Interestingly, GCs contain...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2018-08-10 | PXD005469 | Pride
Axon Psilac 
ProteomicsQuantitative non-canonical amino acid tagging based proteomics identifies distinct patterns of protein synthesis rapidly induced by hypertrophic agents in cardiomyocytes revealing new aspects of metabolic remodeling
cardiomyocytes undergo growth and remodeling in response to specific pathological or physiological conditions. We used pSILAC to identify newly synthesized proteins induced by these stimuli.
ORGANISM(S): Rattus norvegicus (Rat) 
2018-08-13 | PXD004593 | Pride
Cardiac hypertrophy Lc-ms Psilac 
UnknownpSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4CRBN ubiquitin ligase.
Not available
S-EPMC5458144 | biostudies-literature
ProteomicsProfiling C. albicans dimorphism in the human intestine
C. albicans isolates from inflamed and healthy human mucosal tissues exhibit divergent morphology ex vivo. pSILAC proteomic methods were used to explore differences in tissue-invasive behaviour between primary strains derived from healthy controls and patients with inflammatory bowel disease
ORGANISM(S): Candida albicans (Yeast) 
2026-09-22 | PXD027433 | Pride
Candida albicans Psilac Gut infection Quantitative proteomics 
ProteomicspSILAC mass spectrometry reveals ZFP91 as novel IMiD dependent substrate of the CRL4CRBN ligase - PART 2
Thalidomide and its derivatives lenalidomide and pomalidomide (IMiDs) are effective treatments of hematologic malignancies. It was shown that IMiDs impart gain of function properties to the CUL4-RBX1-DDB1-CRBN (CRL4CRBN) ubiquitin ligase that enable binding, ubiquitination and degradation of key the...
ORGANISM(S): Homo sapiens (Human) 
2017-05-29 | PXD005857 | Pride
Imids Silac Lenalidomide Zfp91 
ProteomicspSILAC mass spectrometry reveals ZFP91 as novel IMiD dependent substrate of the CRL4CRBN ligase - PART 1
Thalidomide and its derivatives lenalidomide and pomalidomide (IMiDs) are effective treatments of hematologic malignancies. It was shown that IMiDs impart gain of function properties to the CUL4-RBX1-DDB1-CRBN (CRL4CRBN) ubiquitin ligase that enable binding, ubiquitination and degradation of key the...
ORGANISM(S): Homo sapiens (Human) 
2017-05-29 | PXD005849 | Pride
Imids Cereblon Lenalidomide Crbn Zfp91 
TranscriptomicspSILAC mass spectrometry reveals ZFP91 as novel IMiD dependent substrate of the CRL4CRBN ligase
Thalidomide and its derivatives lenalidomide and pomalidomide (IMiDs) are effective treatments of hematologic malignancies. It was shown that IMiDs impart gain of function properties to the CUL4-RBX1-DDB1-CRBN (CRL4CRBN) ubiquitin ligase that enable binding, ubiquitination and degradation of key the...
ORGANISM(S): Homo sapiens 
2017-03-01 | GSE94728 | GEO
Proteomics,Multiomicsp53-regulated networks of protein, mRNA, miRNA and lncRNA expression revealed by integrated pSILAC and NGS analyses
We determined the effect of p53 activation on de novo protein synthesis using quantitative proteomics of newly synthesized proteins (pulsed stable isotope labeling with amino acids in cell culture, pSILAC) in combination with mRNA and non-coding RNA expression analyses by next generation sequencing ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-05-24 | MSV000079767 | MassIVE
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