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TranscriptomicsExpression comparison between SMC4 and conventional cultures
The undifferentiated state of pluripotent stem cells depends heavily on the culture conditions. We show that a unique combination of small molecules, SMC4, added to culture conditions converts primed pluripotent stem cells to a more naïve state. By conducting Affymetix analysis we show of majority...
ORGANISM(S): Homo sapiens 
2012-03-16 | E-GEOD-28815 | biostudies-arrayexpress
Proteomics3D topology of the SMC2/SMC4 sub-complex from chicken condensin I revealed by cross-linking and molecular modelling
SMC proteins are essential components of three protein complexes that are important for chromosome structure and function. The cohesin complex holds replicated sister chromatids together, whereas the condensin complex has an essential role in mitotic chromosome architecture. Both are involved in int...
ORGANISM(S): Gallus gallus (Chicken) 
2015-07-13 | PXD001835 | Pride
Condensin Cross-linking Mass spectrometry Smc Structure Coiled-coil 
TranscriptomicsExpression comparison between SMC4 and conventional cultures
The undifferentiated state of pluripotent stem cells depends heavily on the culture conditions. We show that a unique combination of small molecules, SMC4, added to culture conditions converts primed pluripotent stem cells to a more naïve state. By conducting Affymetix analysis we show of majority o...
ORGANISM(S): Homo sapiens 
2012-03-16 | GSE28815 | GEO
UnknownUSP39/SMC4 promotes hepatoma cell proliferation and 5-FU resistance.
Not available
S-EPMC11909175 | biostudies-literature
ProteomicsPlasmodium condensin core subunits (SMC2/SMC4) mediate atypical mitosis and are essential for parasite proliferation and transmission
Condensin is a multi-subunit protein complex regulating chromosome condensation and segregation during cell division. In Plasmodium spp., the causative agent of malaria, cell division is atypical and the role of condensin is unclear. Here we examine the role of SMC2 and SMC4, the core subunits of co...
ORGANISM(S): Plasmodium berghei ANKA 
2020-05-27 | PXD016833 | Pride
Condensin Malaria Parasite Lc-ms Scm2 Warwick-rtp Plasmodium berghei Scm4 
UnknownAssociation of SMC4 with prognosis and immune infiltration of sarcoma.
Not available
S-EPMC9925680 | biostudies-literature
UnknownA novel miR-219-SMC4-JAK2/Stat3 regulatory pathway in human hepatocellular carcinoma.
Not available
S-EPMC4096530 | biostudies-literature
UnknownOverexpression of SMC4 activates TGFβ/Smad signaling and promotes aggressive phenotype in glioma cells.
Not available
S-EPMC5533949 | biostudies-literature
ProteomicsThe proteomic study of serially passaged human skin fibroblast cells uncovers down-regulation of SMC4 involved in replicative senescence
In this study, a label-free quantitative proteomic approach was employed to analyze the serial passaged human skin fibroblast （CCD-1079Sk） cells, within 3305 proteins quantified. Of which, 372 proteins were significantly changed in early passage(P6), middle passage (P12) and later passage (P21), wit...
ORGANISM(S): Homo sapiens (Human) Acyrthosiphon pisum (Pea aphid) 
2018-10-22 | PXD007732 | Pride
Proteomic study  human skin fibroblasts  serially passaged  replicative senescence  smc4 
UnknownNFIA-dependent upregulation of SMC4 promotes metastasis and metabolic reprogramming in glioma.
Not available
S-EPMC12417569 | biostudies-literature
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