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TranscriptomicsZeb1 and Snail1 engage miR-200f transcriptional and epigenetic regulation during EMT
Cell plasticity is emerging as a key regulator of tumor progression and metastasis. During carcinoma dissemination epithelial cells undergo epithelial to mesenchymal transition (EMT) processes characterized by the acquisition of migratory/invasive properties, while the reverse, mesenchymal to epithe...
ORGANISM(S): Canis lupus familiaris 
2014-09-09 | E-GEOD-61217 | biostudies-arrayexpress
ProteomicsUSP36 stabilizes nucleolar Snail1 to promote ribosome biogenesis and cancer cell survival upon ribotoxic stress
Tumor growth requires elevated ribosome biogenesis. Targeting ribosomes is an important strategy for cancer therapy. The ribosome inhibitor, homoharringtonine (HHT), is used for the clinical treatment of leukemia, yet it is ineffective for the treatment of solid tumors, the reasons for which remain ...
ORGANISM(S): Homo sapiens (Human) 
2023-09-26 | PXD045622 | Pride
Usp36  snail1  ribosome biogenesis  ribotoxic stress 
ProteomicsProteomic characterization of the role of Snail1 in the differentiation of 3T3-L1 fibroblasts
Snail1 is a transcriptional repressor required for a correct embryonic development. In cancer, Snail1 promotes the epithelial to mesenchymal transition in tumorigenic epithelial cells. In this work, we have analyzed the control of Snail1 in the differentiation of the 3T3-L1 cell line derived from mu...
ORGANISM(S): Mus musculus (Mouse) 
2015-01-06 | PXD001529 | Pride
Adipogenesis Il-17 Obesity Nr2f6 Snail Silac Ltq orbitrap velos 
GenomicsThe role of Snail1 in collective migration
The role of Snail1 in collective migration
PRJNA1259449 | ENA
TranscriptomicsMET after transient Twist activation results in de novo gain of malignant traits
During Epithelial-Mesenchymal Transition (EMT), apical-basal polarized epithelial cells are converted to front-to-back polarized mesenchymal cells that only form loose cell-cell adhesions. These phenotypic changes are accompanied by acquisition of increased motility and invasiveness. EMT programs ar...
ORGANISM(S): Homo sapiens 
2015-07-02 | E-GEOD-61206 | biostudies-arrayexpress
GenomicsCanonical BMP signaling executes epithelial-mesenchymal transition downstream of SNAIL1
Canonical BMP signaling executes epithelial-mesenchymal transition downstream of SNAIL1
PRJNA599935 | ENA
GenomicsSNAIL1 employs β-Catenin-LEF1 complexes to control colorectal cancer cell invasion and proliferation
SNAIL1 employs β-Catenin-LEF1 complexes to control colorectal cancer cell invasion and proliferation
PRJNA475799 | ENA
UnknownSnail1 expression is required for sarcomagenesis.
Not available
S-EPMC4198692 | biostudies-literature
GenomicsExpression profile of select glucose and lipid metabolic genes mediated by STIM1-Snail1 circuit in SMMC7721 cells
Expression profile of select glucose and lipid metabolic genes mediated by STIM1-Snail1 circuit in SMMC7721 cells
PRJNA560517 | ENA
TranscriptomicsSnail1 controls fibroblast action on tumor cell invasion and metastasis [HT29]
Snail1 transcriptional factor is essential for triggering epithelial-to-mesenchymal transition (EMT) and inducing tumor cell invasion. We report here that Snail1 plays also a key role in tumor associated fibroblasts since is necessary for enhancement by these cells on epithelial cells tumor invasion...
ORGANISM(S): Homo sapiens 
2016-12-22 | GSE74056 | GEO
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