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ProteomicsTandem mass tag (TMT) proteomics sequencing analysis on the lung tissues from 12-week-old wild-type Lmna+/+ and LmnaG609G/G609G mice
Hutchinson-Gilford progeria syndrome (HGPS) is a rare and fatal condition characterized by premature aging with an average age of death of 14.5 years. Patients with HGPS age at a rate 5 to 10 times faster than normal individuals and are thought to undergo an accelerated version of normal aging.To in...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-16 | PXD061485 | Pride
S100a6 Mouse Lmnag609g/g609g mice Hgps 
TranscriptomicsLow cost transcriptomic mapping of TMT associated neurotoxicity using human minibrains
RNA sequencing was performed on minibrains exposed to distinct doses and treatment exposures of TMT using BRB sequencing.
ORGANISM(S): Homo sapiens 
2022-05-31 | GSE199502 | GEO
MetabolomicsMulti-Omic Insights into the Cellular Response of Phaeodactylum Tricornutum (Bacillariophyta) Strains under Grazing Pressure

BACKGROUND/AIMS: Phaeodactylum tricornutum, a model organism of diatoms, plays a crucial role in Earth's primary productivity. Investigating its cellular response to grazing pressure is highly significant for the marine ecological environment. Furthermore, the integration of mult...

2023-12-29 | MTBLS8485 | MetaboLights
GenomicsHaloferax volcanii strain:TMT | isolate:cell culture
Haloferax volcanii strain:TMT | isolate:cell culture Genome sequencing
PRJNA1074920 | ENA
TranscriptomicsMultiomics analysis of canine myocardium after circumferential pulmonary vein ablation: Effect of NPY on long-term reinduction of atrial fibrillation
In this study,We established a long-term model of beagle canines after circumferential pulmonary vein ablation (CPVA). The transcriptome and proteome were obtained using high-throughput sequencing and TMT-tagged LC‒MS/LC analysis. Differentially expressed genes and proteins were screened and enriche...
ORGANISM(S): Canis lupus familiaris 
2024-08-14 | GSE248285 | GEO
TranscriptomicsTranscriptomic profiling of HT1080 fibrosarcoma cells of mesenchymal or amoeboid migratory phenotype
Amoeboid and mesenchymal migration of cancer cells both contribute to metastatic spreading of tumors. To characterize gene expression profiles underlying the different migratory modes, we performed RNA sequencing of HT1080 fibrosarcoma cells undergoing mesenchymal-amoeboid transition induced by eith...
ORGANISM(S): Homo sapiens 
2019-07-29 | E-MTAB-6823 | biostudies-arrayexpress
ProteomicsKidney transcriptomic and proteomic analyses provide new insight into the pathogenesis of IgA nephropathy in mice
Background:Immunoglobulin A nephropathy (IgAN) is a common clinically refractory disease, and its pathogenesis remains unclear. Studying the pathogenesis of IgA nephropathy is of great significance for the clinical treatment of IgA nephropathy. Methods:The IgAN mouse model was established through or...
ORGANISM(S): Mus Musculus 
2024-08-15 | PXD054916 |
ProteomicsProteogenomic landscape of multiple myeloma
Multiple myeloma is a plasma cell malignancy of the bone marrow. Despite therapeutic advances, multiple myeloma remains incurable and better risk stratification as well as new therapies are therefore highly needed. The proteome of multiple myeloma has not been systematically assessed before and hold...
ORGANISM(S): Homo sapiens (Human) 
2024-07-09 | PXD038437 | Pride
Multiple myeloma Proteogenomics Plasma cells Therapeutic targets Clinical proteomics Risk signatures Biomarkers 
ProteomicsProteome of the Developing Murine Lens Through Mass Spectrometry
The proteome is a term used for the entire catalog of proteins present in a cell at any time. In here, we investigated the proteome of developing mouse lens through mass spectrometry-based protein sequencing. We extracted mouse lenses at six developmental time points, which included two embryonic (E...
ORGANISM(S): Mus musculus (Mouse) 
2018-01-22 | PXD006381 | Pride
Mouse ocular lens Mass-spectrometry Proteome 
ProteomicsProteomic profiling reveals CDK6 upregulation as a targetable resistance mechanism for lenalidomide in multiple myeloma
The immunomodulatory drugs (IMiDs) lenalidomide and pomalidomide are highly effective treatments for multiple myeloma. However, virtually all patients eventually relapse due to acquired drug resistance with resistance-causing genetic alterations being found only in a small subset of cases. Here, we ...
ORGANISM(S): Homo sapiens (Human) 
2021-12-17 | PXD021265 | Pride
Multiple myeloma Tmt Lc-ms Cdk6 
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