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TranscriptomicsDysregulation of pathways involved in the processing of cancer and microenvironment information in MCA+TPA transformed C3H/10T1/2 cells
The two-stage cell transformation assay is an in vitro model cell culture system to identify the ability of chemicals to act as initiators or promoters of cell transforma- tion and also to study the cellular and molecular mechanisms of chemically induced morphological and neoplastic cell transformat...
ORGANISM(S): Mus musculus 
2013-04-26 | E-GEOD-41142 | biostudies-arrayexpress
TranscriptomicsDifferent response of WT and Ts keratinocyte to TPA treatment
Ts keratinocyte has increased proliferation compare to WT keratinocyte upon TPA treatment. This result showed the different transcription regulation in Ts and WT keratinocyte upon TPA treatment. Total RNA extracted from WT or Ts keratinocytes, not treated or treated with TPA for 12 hours.
ORGANISM(S): Mus musculus 
2013-06-01 | E-GEOD-40382 | biostudies-arrayexpress
TranscriptomicsExpression profiles of human primary keratinocytes differentiated with TPA
Human primary keratinocytes were left untreated or treated for 48 hr with 12-O-tetradecanoylphorbol-13-acetate (TPA) and expression profiles were compared to find long ncRNAs expressed and differentially regulated upon differentiation. 4 replicates of minus TPA and 3 of plus TPA with dye-swap. Custo...
ORGANISM(S): Homo sapiens 
2011-04-12 | E-GEOD-28552 | biostudies-arrayexpress
TranscriptomicsDeletion of DUSP5 affects the expression of a subset of TPA-inducible genes
This experiment was designed to determine if deletion of the dual-specificity MAP kinase phosphatase encoded by DUSP5 had any effect on the pattern of gene expression in cells treated with the phorbol ester tumour promoter TPA. Sex matched primary WT and DUSP5 knockout MEFs were isolated from litter...
ORGANISM(S): Mus musculus 
2014-10-17 | E-GEOD-62433 | biostudies-arrayexpress
TranscriptomicsAge and albumin D site-binding protein control tissue plasminogen activator levels: neurotoxic impact.
Recombinant tissue-type plasminogen activator (tPA) is the fibrinolytic drug of choice to treat stroke patients. However, a growing body of evidence indicates that besides its beneficial thrombolytic role, tPA can also have a deleterious effect on the ischaemic brain. Although ageing influences stro...
ORGANISM(S): Mus musculus 
2009-08-23 | E-GEOD-9004 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human erythroleukemia K562 cells during TPA-induced megakaryocyte differentiation
Analysis of differential gene expression during TPA-induced megakaryocyte differentiation of human erythroleukemia K562 cells. The transcription profile of untreated vs TPA-treated K562 cells for 2 days was compared using gene microarrays.
ORGANISM(S): Homo sapiens 
2009-09-01 | E-MEXP-2213 | biostudies-arrayexpress
TranscriptomicsMicroarray profiling of monocytic differentiaion reveals miRNA-mRNA intrinsic correlation (gene expression)
Since the expression profile of miRNAs is specific in different tissues or under different physiological conditions, the correlations between miRNAs and mRNAs could vary under different biological circumstances. This is a study also used expression profiles of miRNA and mRNA during monocytic differe...
ORGANISM(S): Homo sapiens 
2012-02-02 | E-GEOD-26377 | biostudies-arrayexpress
TranscriptomicsENCODE Transcript Mapping for Total RNA from Human NB4 Cells untreated, treated with RA, and treated with TPA
Transcript Mapping on Affymetrix ENCODE arrays for Total RNA from 4 different samples (2 or 3 technical replicates of each). All of the four same NB4 samples have also been treated with Retanoic Acid (RA) (2 or 3 technical replicates of each). Three of the four same NB4 samples have also been treate...
ORGANISM(S): Homo sapiens 
2010-06-10 | E-GEOD-2679 | biostudies-arrayexpress
ProteomicsProteomic profiling for isolated human peripheral blood neutrophils treated with HRG and tPA
In this study, neutrophils isolated from human peripheral blood were cultured with PBS, tPA(10μg/ml) or tPA+HRG (0.5μm) for 2.5 hours at 37 ° C . Then, neutrophils were collected for proteomic analysis (n=6). Blood sample collection has been approved by Tianjin Medical University General Hospital Et...
ORGANISM(S): Homo sapiens (Human) 
2024-07-15 | PXD051719 | Pride
Tpa Human Neutrophils Protein Histidine-rich glycoprotein 
ProteomicsGlobal quantitative proteomics of mouse brain structures reveals significant alterations in expression of proteins involved in neuronal plasticity during aging
Aging is believed to be the result of alterations of protein expression and accumulation of changes in biomolecules. Although there are numerous reports demonstrating changes in protein expression in brain during aging, only few of them describe global changes in the protein level. Here, we present ...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2018-07-03 | PXD009792 | Pride
Hippocampus Cerebellum Total proteins approach (tpa) Aging Cortex Fasp Mouse brain 
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