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This work aims to detect the differentially expressed proteins between transferrin receptor 1 inhibition and iron chelation in a natural killer cell lymphoma-derived cell line NK92. Cells were treated with 500 μM deferoxamine or 10 μg/mL PPMX-T003 (an anti-transferrin receptor 1 inhibitory antibody)...
ORGANISM(S): Homo Sapiens (human) 
Insights into the mechanism of cell death induced by saporin delivered into cancer cells by an antibody fusion protein targeting the transferrin receptor 1 These studies detail transcriptional changes induced in cancer cells by the complex of saporin (b-SO6) and the antibody fusion protein ch128.1Av...
ORGANISM(S): Homo sapiens 
Human parvovirus B19 (B19V) displays strict tropism for erythroid progenitor cells, governed by the VP1 unique region (VP1u), which mediates cell-specific uptake through interaction with an unknown cellular receptor. Proximity labeling in permissive erythroid cells identified transferrin receptor 1 ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD076389 | Pride
Host nutrient acquisition is essential for apicomplexan parasite infection, yet mechanisms underpinning this are not defined. We discovered the genome of Toxoplasma gondii lacks conserved genes for iron transport and storage and show these host cell proteins including the transferrin receptor 1, tra...
ORGANISM(S): Homo sapiens (Human) Toxoplasma gondii Toxoplasma gondii RH 
2026-10-01 | PXD084269 | Pride

SARS-CoV-2 infection causes severe pulmonary manifestations, with poorly understood mechanisms and limited treatment options. Hyperferritinemia and disrupted lung iron homeostasis in COVID-19 patients imply that ferroptosis, an iron-dependent cell death, may occur. Immunostaining and lipidomic an...

2024-07-11 | MTBLS3107 | MetaboLights
Hepatic Hypoxia-Inducible Factor 1α Mediates Ferroptosis via Transferrin Receptor 1 in Acute Liver Injury
Non-canonical function of transferrin receptor-1 promotes breast cancer metastasis by activating HCK-STAT3-MMP9 signaling
Bloodstream trypanosomes are sensitive to iron starvation, and upregulate ESAG6/7 transferrin receptor (TfR) mRNA and protein levels when placed in low transferrin or iron-depleted media, and adjust TfR expression to compensate for reduced endocytosis. Both observations suggest a specific transcript...
ORGANISM(S): Trypanosoma brucei 
The role of Tfr1 in non-erythroid tissues remains elusive due to the embryonic lethality of the Tfr1 global knockout mouse model. To bypass this problem, we generated a mouse model in which Tfr1 was conditionally deleted in intestinal epithelial cells (IECs). These mice developed severe IEC disrup...
ORGANISM(S): Mus musculus 
Disruption of local iron homeostasis is a common feature of neurodegenerative diseases. We focused on dopaminergic neurons, asking how iron transport proteins modulate iron homeostasis in vivo. Inactivation of the transmembrane iron exporter ferroportin had no apparent consequences. However, loss of...
ORGANISM(S): Mus musculus 
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