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TranscriptomicsUromodulin-retention in thick ascending limb affects SCD1 in neighboring S3 proximal tubule in males: transcriptome studies in mouse models of Uromodulin-associated kidney disease
Uromodulin-associated kidney disease (UAKD) summarizes different clinical features of an autosomal dominant heritable disease syndrome in humans with a proven uromodulin (UMOD) mutation involved. It is often characterized by hyperuricemia, gout, alteration of urine concentrating ability, as well as ...
ORGANISM(S): Mus musculus 
2014-10-01 | E-GEOD-58513 | biostudies-arrayexpress
ProteomicsThe kidney releases in the urine and circulation a non-polymerizing form of Uromodulin that retains the external hydrophobic patch domain
Uromodulin (Tamm-Horsfall protein, THP) is a glycoprotein uniquely produced in the kidney. It is released by cells of the thick ascending limbs (TAL) apically in the urine, and basolaterally in the renal interstitium and systemic circulation. Processing of mature urinary THP, which polymerizes into ...
ORGANISM(S): Homo sapiens (Human) 
2022-11-08 | PXD027914 | Pride
Uromodulin Lc-msms Aki External hydrophobicpatch domain Urine Serum Elisa Human 
TranscriptomicsTranscriptional profiling of renal cells expressing wild type or mutant uromodulin isoforms.
Uromodulin is the most abundant urinary protein. It is exclusively produced and released in the urine by renal epithelial cells lining the thick ascending limb of Henle’s loop (TAL). Mutations in UMOD, the gene encoding uromodulin, cause autosomal dominant tubulointerstitial kidney disease uromoduli...
ORGANISM(S): Mus musculus 
2017-05-04 | GSE92704 | GEO
UnknownRole of Uromodulin in Salt-Sensitive Hypertension.
Not available
S-EPMC9553220 | biostudies-literature
ProteomicsCharacterization of kidney-specific and site-specific N-glycosylation signatures of isolated uromodulin from human urine
Uromodulin (Umod, Tamm–Horsfall protein), as the most abundant urinary N-glycoprotein exclusively produced by the kidney, can form filaments to antagonize the adhesion of uropathogens. However, the kidney-specific and site-specific N-glycosylation signatures of this glycoprotein remain poorly unders...
ORGANISM(S): Homo Sapiens 
PXD041640 |
UnknownSerum uromodulin in dogs with chronic kidney disease.
Not available
S-EPMC9708433 | biostudies-literature
UnknownUromodulin exclusion list improves urinary exosomal protein identification.
Not available
S-EPMC3221452 | biostudies-literature
UnknownUromodulin in kidney injury: an instigator, bystander, or protector?
Not available
S-EPMC3288726 | biostudies-literature
TranscriptomicsDendritic cells from mice with an uromodulin mutation demonstrate changes in gene expression resulting in increased migration and efferocytosis capability
Introduction: The effects of Uromodulin on the innate immune system remain uncertain. Mice with a cysteine to phenylalanine mutation (C105F) in the UMOD gene homologous to a pathogenic human mutation demonstrate high levels of circulating uromodulin following ischemia reperfusion kidney injury, incr...
ORGANISM(S): Mus musculus 
2022-08-06 | GSE210500 | GEO
TranscriptomicsUromodulin-retention in thick ascending limb affects SCD1 in neighboring S3 proximal tubule in males: transcriptome studies in mouse models of Uromodulin-associated kidney disease
Uromodulin-associated kidney disease (UAKD) summarizes different clinical features of an autosomal dominant heritable disease syndrome in humans with a proven uromodulin (UMOD) mutation involved. It is often characterized by hyperuricemia, gout, alteration of urine concentrating ability, as well as ...
ORGANISM(S): Mus musculus 
2014-10-01 | GSE58513 | GEO
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