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ProteomicsStructural Dynamics of the Ubiquitin Specific Protease USP30 in Complex with a Cyanopyrrolidine-Containing Covalent Inhibitor Structural Dynamics of the Ubiquitin Specific Protease USP30 in Complex with a Cyanopyrrolidine-Containing Covalent Inhibitor
Inhibition of the mitochondrial deubiquitinating enzyme USP30 is neuroprotective and presents therapeutic opportunities for the treatment of idiopathic Parkinson’s Disease and mitophagy-related disorders. We have integrated structural and quantitative proteomics with biochemical assays to decipher t...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054057 | Pride
Ubiquitin specific protease usp30  cyanopyrrolidine inhibitors Activity-based protein profiling mass spectrometry  enzyme kinetics  hydrogen deuterium exchange-mass spectrometry  molecular docking Mitophagy 
ProteomicsStructural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides
Dampening functional levels of the mitochondrial deubiquitylating enzyme USP30 has been suggested as an effective therapeutic strategy against neurodegenerative disorders such as Parkinson’s Disease. USP30 inhibition may counteract the deleterious effects of impaired turnover of damaged mitochondria...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD041582 | Pride
Abpp-ms Usp30 Hdx-ms 
ProteomicsA novel USP30 inhibitor recapitulates genetic loss of USP30 and sets the trigger for PINK1-PARKIN amplification of mitochondrial ubiquitylation.
The mitochondrial deubiquitylase USP30 negatively regulates the selective autophagy of damaged mitochondria. It has been proposed as an actionable target to alleviate the loss of function of the mitophagy pathway governed by the Parkinson’s Disease associated genes PINK1 and PRKN. We present the cha...
ORGANISM(S): Homo sapiens (Human) 
2020-07-03 | PXD018640 | Pride
Ubiquitylome Mitophagy Lc-ms Deubiquitylase Usp30 Parkinson’s disease Dub inhibitor Ubiquitin 
ProteomicsStructural Dynamics of the Ubiquitin Specific Protease USP30 in Complex with a Cyanopyrrolidine-Containing Covalent Inhibitor
Inhibition of the mitochondrial deubiquitinating enzyme USP30 is neuroprotective and presents therapeutic opportunities for the treatment of idiopathic Parkinson’s Disease and mitophagy-related disorders. We have integrated structural and quantitative proteomics with biochemical assays to decipher t...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054041 | Pride
Ubiquitin specific protease usp30  cyanopyrrolidine inhibitors Activity-based protein profiling mass spectrometry  enzyme kinetics  hydrogen deuterium exchange-mass spectrometry  molecular docking Mitophagy 
ProteomicsStructural Premise of Selective Deubiquitinase USP30 Inhibition by Small- Molecule Benzosulfonamides
Dampening functional levels of the mitochondrial deubiquitylating enzyme USP30 has been suggested as an effective therapeutic strategy against neurodegenerative disorders such as Parkinson’s Disease. USP30 inhibition may counteract the deleterious effects of impaired turnover of damaged mitochondria...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD036574 | Pride
Ubiquitin Usp30 Abpp Benzosulfonamides Hdx-ms 
ProteomicsA novel USP30 inhibitor recapitulates genetic loss of USP30 and sets the trigger for PINK1-PARKIN amplification of mitochondrial ubiquitylation
The mitochondrial deubiquitylase USP30 negatively regulates the selective autophagy of damaged mitochondria. It has been proposed as an actionable target to alleviate the loss of function of the mitophagy pathway governed by the Parkinson’s Disease associated genes PINK1 and PRKN. We present the cha...
ORGANISM(S): Homo sapiens (Human) 
2020-07-03 | PXD019692 | Pride
Ubiquitylome Mitophagy Deubiquitylase Usp30 Parkinson’s disease Dub inhibitor Ubiquitin 
ProteomicsDiscovery of highly Potent and Selective Activity-Based Probes for the Deubiquitylating Enzyme USP30
Ubiquitin-specific protease 30 (USP30) is a deubiquitylating enzyme (DUB) localized in the mitochondrial membrane, which is related to PINK1/Parkin-mediated mitophagy, pexophagy, BAX/BAK-dependent apoptosis, and IKKβ-USP30-ACLY-regulated lipogenesis/tumorigenesis. Mission therapeutics pointed their ...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD044792 | Pride
Usp30  activity-based probes  chemical probes  desi  deubiquitinase. 
GenomicsThe impact of USP30-AS1 knockdown on gene expression in MDA-MB-231 cell line
The impact of USP30-AS1 knockdown on gene expression in MDA-MB-231 cell line
PRJNA1140862 | ENA
TranscriptomicsThe impact of USP30-AS1 knockdown on gene expression in MDA-MB-231 cell line
We discovered that USP30-AS1 is significantly upregulated in breast cancer tissues and is closely associated with the cell proliferation signaling pathway. Knockdown of USP30-AS1 notably inhibits cell proliferation in MDA-MB-231 breast cancer cells. USP30-AS1 inhibits the expression of the cell cycl...
ORGANISM(S): Homo sapiens 
2024-08-31 | GSE273249 | GEO
ProteomicsStructural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides
Dampening functional levels of the mitochondrial deubiquitylating enzyme USP30 has been suggested as an effective therapeutic strategy against neurodegenerative disorders such as Parkinson’s Disease. USP30 inhibition may counteract the deleterious effects of impaired turnover of damaged mitochondria...
ORGANISM(S): Homo Sapiens 
2026-01-12 | PXD042782 | panorama
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