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TranscriptomicsLoss of Usp9x increases Wnt and Notch signaling in neural progenitors
Correct neural progenitor fate determination requires the coordination of extrinsic fate determinant signals with intrinsic responses. Post-translational modifications dynamically alter protein function and so are ideally situated to regulate development. Here we show that the deubiquitylaying enzym...
ORGANISM(S): Mus musculus 
2017-08-18 | E-MTAB-4150 | biostudies-arrayexpress
ProteomicsIdentification of a USP9X Substrate NFX1-123 by SILAC-based Quantitative Proteomics
The deubiquitinase USP9X related with multiple diseases including neurodegeneration, epilepsy and various type of tumor, by targeting different substrates. In our study, to deep study USP9X functional candidate substrates, we performed SILAC-based quantitative proteomic to compare knockdown USP9X w...
ORGANISM(S): Homo sapiens (Human) 
2019-05-13 | PXD012871 | Pride
Usp9x nfx1-123 silac 
ProteomicsUbiquitin remnant analysis in melanoma post inhibition of Usp9x
Assay the ubiquitinated protein remmants post depletion or inhibition of the deubiquitinase Usp9x in melanoma cells.
ORGANISM(S): Homo sapiens (Human) 
2017-02-20 | PXD005417 | Pride
Usp9x G9 Inhibitor Melanoma Deubiquitinase 
ProteomicsIdentification of mitotic substrates of phospho-regulated USP9X
We previously identified the deubiquitylase USP9X as a G2/M-specific CDC14B interactor (PXD012732) and subsequently identified USP9X as a specific CDC14B target (PXD012733). To investigate relevant mitotic substrates of phospho-regulated USP9X, we next performed a Stable isotope labeling by amino ac...
ORGANISM(S): Homo sapiens (Human) 
2020-03-25 | PXD012734 | Pride
Usp9x Ubiquitinylation 
ProteomicsUSP9X phosphopeptide mapping - We previously identified the deubiquitylase USP9X as a G2/M-specific CDC14B interactor (PXD012732). The functional connection of these proteins has been further investigated by a quantitative comparison of USP9X phosphorylation in WT vs CDC14B-overexpressing HEK 293Tcells (ATCC® CRL-3216™). The approach identified USP9X serine 2563 as a specific CDC14B target. Phosphorylation at USP9XS2563 has been confirmed by in-house phosphospecific antibodies.
We previously identified the deubiquitylase USP9X as a G2/M-specific CDC14B interactor (PXD012732). The functional connection of these proteins has been further investigated by a quantitative comparison of USP9X phosphorylation in WT vs CDC14B-overexpressing HEK 293Tcells (ATCC® CRL-3216™). The appr...
ORGANISM(S): Homo sapiens (Human) 
2020-03-25 | PXD012733 | Pride
Cdc14b Usp9x 
ProteomicsA novel USP9X substrate TTK contributes to tumorigenesis in non-small cell lung cancer
The X-linked deubiquitinase, USP9X, is implicated in multiple cancers by targeting various substrates. Increased expression of USP9X is observed in non-small cell lung cancer (NSCLC) and is correlated with poor prognosis. However, the molecular mechanism for USP9X regulating tumor cell survival and ...
ORGANISM(S): Homo sapiens (Human) 
2018-05-07 | PXD007726 | Pride
Non-small cell lung cancer (nsclc)  quantitative proteomics  deubiquitinase  usp9x  ttk 
ProteomicsGlobal analysis of cancer cell responses to USP9X inhibition
HDX-MS experiment using selective USP9X inhibitors WEHI-092, FT709 with recombinant catalytic domain USP9X.
ORGANISM(S): Homo sapiens (Human) 
2026-04-09 | PXD062754 | Pride
ProteomicsUSP9X coordinates TGF-β and hypoxia signalings to promote ovarian cancer chemoresistance via maintaining cancer stem cells
Widespread intraperitoneal metastases and chemoresistance has made ovarian cancer the leading cause of gynecological malignancy–related deaths, wherein TGF-β signaling plays the pivotal role by promoting cancer stem cells (CSCs) activity. Whereas, how the signaling is activated and how to target TGF...
ORGANISM(S): Homo Sapiens 
2024-03-08 | PXD050476 |
GenomicsThe deubiquitinase Usp9x regulates PRC2-mediated chromatin reprogramming during mouse development
The deubiquitinase Usp9x regulates PRC2-mediated chromatin reprogramming during mouse development
PRJNA611997 | ENA
ProteomicsDeubiquitinase USP9X loss sensitizes renal cancer cells to mTOR inhibition
mTOR is a central regulator of mammalian metabolism and physiology. Aberrant hyperactivation of this pathway promotes tumor growth and metastasis and drives tumor resistance to chemotherapy and cancer drugs, making mTOR an attractive cancer therapeutic target. mTOR inhibitors have been approved to t...
ORGANISM(S): Homo sapiens (Human) 
2023-06-14 | PXD040496 | Pride
Ubiquitinase Usp9x Human Renal cancer Mtor 
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