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ProteomicsTop-down Proteomics of Large Proteins Up to 223 kDa Enabled by Serial Size Exclusion Chromatography Strategy
Mass spectrometry (MS)-based top-down proteomics is a powerful method for the comprehensive analysis of proteoforms that arise from genetic variations and post-translational modifications (PTMs). However, top-down MS analysis of high molecular weight (MW) proteins remains challenging mainly due to t...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-11-29 | MSV000080365 | MassIVE
ProteomicsTop-down murine MMTV-PyMT proteoform landscape
We developed a top-down proteomic approach to characterize late-stage, primary tumor tissues harvested from MMTV-PyVT mice. This methodology allowed us to expand the coverage for high MW proteoforms using a murine model of breast cancer.
ORGANISM(S): Mus musculus (Mouse) 
2026-03-16 | PXD059164 | Pride
Post-translational modifications 2d-sec-rpc-ms High molecular weight proetoforms Breast cancer Proteoform Mmtv-pymt tumors 
UnknownTop-Down Proteomics of Large Proteins up to 223 kDa Enabled by Serial Size Exclusion Chromatography Strategy.
Not available
S-EPMC5511113 | biostudies-literature
ProteomicsInvestigation of Plasmodium vivax trophozoite-schizont transition proteome
The apicomplexan parasite Plasmodium vivax reportedly caused 13.8 million cases of vivax malaria in 2015. Much of the unique biology of this pathogen remains unknown. To expand our proteomics interrogation of the blood-stage interaction with its host animal model Saimiri boliviensis, we analyzed the...
ORGANISM(S): Saimiri boliviensis boliviensis Plasmodium vivax Sal-1 
2017-08-07 | PXD005769 | Pride
Lc ms/ms Msgf Sequest Infected red blood cell Systems biology Malaria Saimiri boliviensis Mascot Crux Mahpic Plasmodium vivax Reticulocyte Schizont Trophozoite Andromeda 
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