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MetabolomicsBiochemical Profiling of the Brain and Blood Metabolome in a Mouse Model of Prodromal Parkinson’s Disease Reveals Distinct Metabolic Profiles (NMR assay)
Parkinson’s disease is the second most common neurodegenerative disease. In the vast majority of cases the origin is not genetic and the cause is not well understood, although progressive accumulation of α-synuclein aggregates appears central to the pathogenesis. Currently, treatments that slow dise...
2019-02-07 | MTBLS640 | MetaboLights
MetabolomicsMass spectrometry imaging as an emerging tool for studying metabolism in human brain organoids

Human brain organoids are emerging models to study human brain development and pathology as they recapitulate the development and characteristics of major neural cell types, and enable manipulation through an in vitro system. Over the past decade, with the advent of spatial technologies,...

2023-05-23 | MTBLS7565 | MetaboLights
ProteomicsAssessing inter-line reproducibility of a novel iPSC-derived 3D brain tissue model (3BTM) and comparison to 2D co-cultures
Stem-cell-based in vitro models offer promising potential to elucidate human brain cell functions and interactions under healthy conditions and in disease states. However, harnessing this potential is currently impaired by low reproducibility, maturity, and cell-type diversity of models. Therefore, ...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD069984 | Pride
3d brain tissue model 3btm Brain Ipsc 
ProteomicsProteomic analysis of a novel iPSC-derived 3D brain tissue model (3BTM) of Alzheimer’s disease
Stem-cell-based in vitro models offer promising potential to elucidate pathomechanisms underlying neurological diseases such as Alzheimer’s disease. However, harnessing this potential is currently impaired by low reproducibility, maturity, and cell-type diversity of models and lack of AD-relevant pa...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD071849 | Pride
3d brain tissue model Alzheimer’s disease 3btm Brain Ipsc 
ProteomicsProteomic analysis of a novel iPSC-derived 3D brain tissue model (3BTM) of Alzheimer’s disease
Stem-cell-based in vitro models offer promising potential to elucidate pathomechanisms underlying neurological diseases such as Alzheimer’s disease. However, harnessing this potential is currently impaired by low reproducibility, maturity, and cell-type diversity of models and lack of AD-relevant pa...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD055254 | Pride
Dia Ipsc Label-free Human Cortical tissue model 
ProteomicsExtracellular vesicles secreted by 3D tumor organoids are enriched for immune regulatory signaling biomolecules compared to conventional 2D glioblastoma cell systems
Background: Newer 3D culturing approaches are a promising way to better mimic the in vivo tumor microenvironment and to study the interactions between the heterogeneous cell populations of glioblastoma multiforme. Like many other tumors, glioblastoma uses extracellular vesicles as an intercellular c...
ORGANISM(S): Homo sapiens (Human) 
2024-04-09 | PXD047328 | Pride
Ev Extracellular vesicle Proteomics Microrna 3d organoid model Brain cancer Glioblastoma multiforme 
TranscriptomicsDNA Microarray Analysis Approach for Unraveling the Ischemic Mouse Brain Transcriptome
Brain ischemia, also termed cerebral ischemia, is a condition in which there is insufficient blood flow to the brain to meet metabolic demand, and results in brain tissue death (cerebral infarction) due to poor oxygen supply (cerebral hypoxia). Our group is interested in the protective effects of ne...
ORGANISM(S): Mus musculus 
2012-03-31 | E-GEOD-28201 | biostudies-arrayexpress
TranscriptomicsTranscruption profiling of human cerebellum, frontal cortex [BA4, BA9] and caudate nucleus HD tissue experiment
Post mortem human brain tissue comparison between HD patients and controls from 3 brain regions - cerebellum, frontal cortex [BA4, BA9] and caudate nucleus. Gene expression analysed using linear models from LIMMA package in Bioconductor suite. Experiment Overall Design: Large sample sizes were used...
ORGANISM(S): Homo sapiens 
2009-09-12 | E-GEOD-3790 | biostudies-arrayexpress
UnknownRecapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition.
Not available
S-EPMC3525561 | biostudies-literature
GenomicsMitochondria dysregulation contributes to secondary neurodegeneration progression post-contusion injury in human 3D in vitro triculture brain tissue model.
Mitochondria dysregulation contributes to secondary neurodegeneration progression post-contusion injury in human 3D in vitro triculture brain tissue model.
PRJNA993402 | ENA
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