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ProteomicsRecombinant HIV-1 426c Env Tryptic Digest Glycan Identifications and Semi-Quantification
VRC01-class broadly neutralizing antibodies (bnAbs) target the CD4-binding site (CD4BS) of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein (Env) and are of major interest for vaccine design. Unlike mature antibodies, corresponding VRC01-class germline precursors poorly bind to Env d...
ORGANISM(S): Human immunodeficiency virus 1 Homo sapiens 
2018-11-21 | PXD011494 | Pride
Mannose Immunogen Oligosaccharide Xray crystallography Glycan Vrc01 Hiv-1 Endoh 426c Vaccine Glvrc01 Cryoem Human immunodeficiency virus Hiv Vrc01gl Gp120 
UnknownGermline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer and a glycosylated HIV-1 gp120 core.
Not available
S-EPMC6237438 | biostudies-literature
ProteomicsOvercoming steric restrictions of VRC01 HIV-1 neutralizing antibodies through immunization
Broadly HIV-1 neutralizing VRC01-class antibodies target the CD4-binding site of Env. They are derived from VH1-2*02 antibody heavy chains paired with rare light chains expressing five amino acid long CDRL3s. They have been isolated from infected subjects but have not yet been elicited by immunizati...
ORGANISM(S): Human immunodeficiency virus 1 Homo sapiens 
2020-05-26 | PXD015168 | Pride
Immunization Hiv N276 Glycan Vrc01 426c core Mice Antibody Bnab 
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