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ProteomicsOvercoming steric restrictions of VRC01 HIV-1 neutralizing antibodies through immunization
Broadly HIV-1 neutralizing VRC01-class antibodies target the CD4-binding site of Env. They are derived from VH1-2*02 antibody heavy chains paired with rare light chains expressing five amino acid long CDRL3s. They have been isolated from infected subjects but have not yet been elicited by immunizati...
ORGANISM(S): Human immunodeficiency virus 1 Homo sapiens 
2020-05-26 | PXD015168 | Pride
Immunization Hiv N276 Glycan Vrc01 426c core Mice Antibody Bnab 
ProteomicsRecombinant HIV-1 426c Env Tryptic Digest Glycan Identifications and Semi-Quantification
VRC01-class broadly neutralizing antibodies (bnAbs) target the CD4-binding site (CD4BS) of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein (Env) and are of major interest for vaccine design. Unlike mature antibodies, corresponding VRC01-class germline precursors poorly bind to Env d...
ORGANISM(S): Human immunodeficiency virus 1 Homo sapiens 
2018-11-21 | PXD011494 | Pride
Mannose Immunogen Oligosaccharide Xray crystallography Glycan Vrc01 Hiv-1 Endoh 426c Vaccine Glvrc01 Cryoem Human immunodeficiency virus Hiv Vrc01gl Gp120 
GenomicsCricetulus griseus strain:VRC01 CHOK1
Effects of ammonia stress on recombinant CHO-K1 cells expressing the anti-HIV antibody VRC01 (IgG1)
PRJNA599947 | ENA
GenomicsMus musculus breed:C57BL/6J
BCR sequencing of transgenic VRC01 B cells.
PRJNA802246 | ENA
UnknownAdjuvants influence the maturation of VRC01-like antibodies during immunization.
Not available
S-EPMC9667313 | biostudies-literature
UnknownNeutralizing antibody VRC01 failed to select for HIV-1 mutations upon viral rebound.
Not available
S-EPMC7259993 | biostudies-literature
UnknownMechanism of neutralization by the broadly neutralizing HIV-1 monoclonal antibody VRC01.
Not available
S-EPMC3165784 | biostudies-literature
UnknownDevelopment of a VRC01-class germline targeting immunogen derived from anti-idiotypic antibodies.
Not available
S-EPMC8127986 | biostudies-literature
UnknownDelayed vaginal SHIV infection in VRC01 and anti-α4β7 treated rhesus macaques.
Not available
S-EPMC6533011 | biostudies-literature
OtherMutational tolerance of HIV-1 Env in the CD4, VRC01 and PG16 bound states
HIV-1 infection begins with binding of the viral envelope glycoprotein Env to the host receptor CD4, triggering a series of conformational changes that lead to fusion of the virus and cell membranes. Env, a trimer of gp120 and gp41 subunits, occupies a ‘closed’ conformation with contacts between gp1...
ORGANISM(S): Human immunodeficiency virus 1 
2019-02-03 | GSE102276 | GEO
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