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ProteomicsAntimycin A-treated vs ETFDH-ko myoblasts TMT
The electron transfer flavoprotein dehydrogenase (ETFDH) is the bottleneck enzyme of fatty acid oxidation (FAO). We performed a TMT 6plex analysis on Antimycin A treated and ETFDH-ko myoblasts (compared to CRL).
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD045588 | Pride
Myoblast Tmt Etfdh Antimycin a 
ProteomicsCharacterization of odontogenic differentiation from human dental pulp stem cells using TMT-based proteomic analysis
The repair of dental pulp injury relies on the odontogenic differentiation of dental pulp stem cells (DPSCs). To better understand the odontogenic differentiation of DPSCs and identify proteins involved in this process, tandem mass tags (TMTs) coupled with liquid chromatography-tandem mass spectrome...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD021279 | Pride
Tmt-label Hdpscs Odontogenesis 
ProteomicsC2C12 myoblast WT vs ETFDH-ko TMT
ETFDH (electron transfer flavoprotein ubiquinone oxidoreductase) is a 64 kDa protein monomer located in the inner mitochondrial membrane, in charge of transferring the electrons received from the electron transfer flavoprotein ETF to the Coenzyme Q (Q). Pathological mutations in ETFDH lead to Multip...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD041825 | Pride
Mouse Myoblast Tmt Etfdh C2c12 
ProteomicsTMT-based proteomics analysis of proteome changes in Ck137956-/- mouse round spermatids
The proteome changes were quantified in Ck137956-/- mouse round spermatids using TMT 6-plex by LC-MS/MS.
ORGANISM(S): Mus musculus (Mouse) 
2023-04-01 | PXD036804 | Pride
Mouse Round spermatids Tmt Ck137956-/- 
ProteomicsRTNs and DP1 Knockdown in neurons
Quantitative proteomics results of RTNs-KD neurons or DP1-KD neurons (DIV5). Peptides derived from Untreated neurons (UNT) were chemically labeled with TMT-126, pSuper-neurons with TMT-127, shRNAs_RTNs-neurons with TMT-128 and shRNA_DP1-neurons with TMT-131.
ORGANISM(S): Rattus norvegicus (Rat) 
2019-02-15 | PXD012264 | Pride
Cortical neurons Rtn Tmt labeling Dp1 Shrna. 
ProteomicsQuantitative proteomic and phosphoproteomic profiling of Sh3rf3-deficient ASD mouse model via 6Plex-TMT and phosphoproteomic
This study aims to systematically investigate the molecular mechanisms underlying autism spectrum disorder (ASD) by analyzing the proteome and phosphoproteome of a Sh3rf3-deficient mouse model. SH3RF3 (SH3 domain-containing RING finger protein 3) is implicated in synaptic regulation pathways, yet it...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-23 | PXD061722 | Pride
Prefrontal cortex Mouse Ms Sh3rf3 
ProteomicsEvaluation of a Dual Isolation Width Acquisition (DIWA) method for isobaric labelling ratio decompression
Stable isotope labelling of peptides using isobaric reagents such as iTRAQ and TMT enables the multiplexed analysis of proteomes with deep quantitative coverage. Isobaric tagging demonstrates high precision but imperfect accuracy due to ratio underestimation caused by co-fragmentation of ions with m...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2019-01-07 | PXD010571 | Pride
Method development Tmt Msms Diwa 
ProteomicsProteomic profiling of sclerosis hippocampus revealed dysregulated packaging of vesicular neurotransmitters in temporal lobe epilepsy
Proteomics and bioinformatic analyses of hippocampus were performed. High-resolution liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS), in combination with TMT-6plex quantification, was applied for global protein expression analysis. The proteomics results were validated by Wester...
ORGANISM(S): Homo sapiens (Human) 
2020-07-17 | PXD010544 | Pride
Temporal lobe epilepsy Proteomics Vesicle transmitters packaging Hippocampus sclerosis Annexin 
ProteomicsProteomic profiling of sclerosis hippocampus revealed dysregulated packaging of vesicular neurotransmitters in temporal lobe epilepsy
Proteomics and bioinformatic analyses of hippocampus were performed. High-resolution liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS), in combination with TMT-6plex quantification, was applied for global protein expression analysis. The proteomics results were validated by Wester...
ORGANISM(S): Homo sapiens (Human) 
2020-07-17 | PXD010543 | Pride
Temporal lobe epilepsy Proteomics Vesicle transmitters packaging Hippocampus sclerosis Annexin 
ProteomicsTMT proteomic analysis of thyroid cancer tissue sample
Our study aimed to adopt a proteomics strategy for analysing changes in the levels of proteins between PTC and para-tumour specimens. A integrative strategy was adopted to identify the important pathways in PTC.
ORGANISM(S): Homo sapiens (Human) 
2021-12-14 | PXD027538 | Pride
Human Tissue Tmt Thyroid cancer 
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