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ProteomicsIdentification of novel biomarkers for aortic aneurysm
To discover novel biomarkers for aortic aneurysm, serum samples of patients with thoracic aortic aneurysm were fractionated, tryptic digested, and subjected to proteome analysis.
ORGANISM(S): Homo Sapiens (human) 
2023-11-15 | PXD033774 | JPOST Repository
ProteomicsAortic Aneurysm iTRAQ HiRIEF proteomics
Conducted proteomics on samples from patients with aortic aneurysm and from non-dilated controls. Furthermore, we investigated both patients with bicuspid aortic valves (BAV) and also the more normal tricuspid aortic valves (TAV). The aim was to elucidate the molecular mechanisms behind the higher p...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080837 | MassIVE
Proteomicsabdominal aortic aneurysm (AAA) proteomics
An abdominal aortic aneurysm (AAA) is a pathological dilatation of the aortic wall and it is a life-threatening disease due to the risk of rupture. Currently, surgical intervention remains the only definitive treatment recommended for large or rapidly expanding aneurysms. No pharmacological therapy ...
ORGANISM(S): Homo sapiens (Human) 
2025-09-29 | PXD067859 | Pride
Dia-ms Human tissue Abdominal aortic aneurysm 
TranscriptomicsTranscription profiling of human patients with aortic aneurysms associated with tricuspid and bicuspid valves
Patients with bicuspid aortic valve (BAV) have increased risk of thoracic ascending aortic aneurysm (AscAA) and dissection compared to those with a normal tricuspid aortic valve (TAV). The present study was undertaken to evaluate whether differences in gene expression exist in aortas from BAV and TA...
ORGANISM(S): Homo sapiens 
2009-02-07 | E-GEOD-5180 | biostudies-arrayexpress
TranscriptomicsMicroRNA transciptional profiling in murine abdominal aortic aneurysm (AAA), porcine pancreatic elastase (PPE) model - Day 7
We sought to identify differentially regulated microRNAs in infrarenal mouse aortic tissue after AAA-induction with PPE, compared with sham-operated mice. This treatment leads to rapid development of infrarenal aortic aneurysms with significant diameter differences observed by Day 7. We found 41 miR...
ORGANISM(S): Mus musculus 
2014-08-31 | E-GEOD-51226 | biostudies-arrayexpress
TranscriptomicsMurine Abdominal Aortic Aneurysm, PPE Model: Transcriptional Profiling of Sham vs. AAA at Day 7
Transcriptional profiling of infrarenal aortic tissue from Male 10-week-old C57BL/6J mice after AAA-induction with porcine pancreatic elastase, compared with sham-operated mice. Includes samples obtained 7 days after aneurysm induction. Goal was to examine gene expression in developing AAA in this m...
ORGANISM(S): Mus musculus 
2014-08-31 | E-GEOD-51227 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of peripheral blood from patients with abdominal aortic aneurysms
We performed two different pools for the 10 AAA patients (n=5 AAA patients in pool A and n=5 AAA patients in pool B) and two different pools for the 10 healthy subjects (n=5 controls in pool C and n=5 controls in pool D). Two replicates of the two microarray experiments were made. Experiment 1: AAA...
ORGANISM(S): Homo sapiens 
2008-02-15 | E-MEXP-1346 | biostudies-arrayexpress
Proteomicsabdominal aortic aneurysm (AAA) plasma proteomics
An abdominal aortic aneurysm (AAA) is a pathological dilatation of the aortic wall and it is a life-threatening disease due to the risk of rupture. Currently, surgical intervention remains the only definitive treatment recommended for large or rapidly expanding aneurysms. No pharmacological therapy ...
ORGANISM(S): Homo sapiens (Human) 
2026-05-21 | PXD068130 | Pride
Abdominal aortic aneurysm (aaa) Human Plasma Patient 
ProteomicsCycloastragenol inhibit experimental abdominal aortic aneurysm progression
Abstract: The pathogenesis of AAA involves vascular inflammation and oxidative stress. Astragali Radix contains cycloastragenol (CAG) known to have anti-inflammatory and anti-oxidative properties. We hypothesized that CAG supplement impairs AAA progression. AAA was induced in male rats by intralumi...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-05-20 | PXD030441 | Pride
Aortic aneurysm  pathogenesis  pharmacological therapy  experimental model  drug delivery 
TranscriptomicsGene expression study in Positron Emission Tomography (PET) positive abdominal aortic aneurysms
This study aims at identifying genes involved in this metabolic activation potentially related to rupture. A genome-wide transcriptomic analysis was performed on biopsies collected from patients with a Fluorodeoxyglucose (FDG) uptake both in the positive spot (A+Pos) and in a distant negative site o...
ORGANISM(S): Homo sapiens 
2015-02-09 | E-MTAB-3175 | biostudies-arrayexpress
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