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TranscriptomicsTranscription profiling of rat blood and liver exposed to acetaminophen (APAP)
This SuperSeries is composed of the following subset Series:; GSE5593: Acetaminophen (APAP) Rat Blood Training Gene Expression Data Set; GSE5594: Acetaminophen (APAP) Rat Blood Test Gene Expression Data Set; GSE5595: Acetaminophen (APAP) Rat Liver Test Gene Expression Data Set; The Supplementary fil...
ORGANISM(S): Rattus norvegicus 
2008-06-14 | E-GEOD-5652 | biostudies-arrayexpress
Transcriptomicsp53 Contributes to Differentiating Gene Expression Following Exposure to Acetaminophen and Its Less Hepatotoxic Regioisomer Both In Vitro and In Vivo
The goal of the present study was to compare hepatic toxicogenomic signatures across in vitro and in vivo mouse models following exposure to acetaminophen (APAP) or its relatively nontoxic regioisomer 3'-hydroxyacetanilide (AMAP). Two different Affymetrix microarray platforms and one Agilent Oligonu...
ORGANISM(S): Mus musculus 
2016-03-29 | E-GEOD-56576 | biostudies-arrayexpress
TranscriptomicsDifferential Regulation of Mitogen-Activated Protein Kinases by Acetaminophen in TAMH cells
Acetaminophen (APAP), a widely used analgesic and antipyretic that is considered to be relatively safe at recommended doses, is the leading cause of drug-induced liver failure in the United States. 3M-bM-^@M-^Y-Hydroxyacetanilide (AMAP), a regioisomer of acetaminophen is useful as a comparative too...
ORGANISM(S): Mus musculus 
2010-07-06 | E-GEOD-18614 | biostudies-arrayexpress
TranscriptomicsDiscover preclinical biomarkers of hepatotoxicity: Acetaminophen and Carbon tetrachloride
Preclinical biomarkers useful for identification of idiosyncratic drugs have not been identified. It is hypothesized that patterns of transcript expression for the hepatotoxicants, including classical and idiosyncratic hepatotoxicants, are similar and the patterns differ from those of non-hepatotox...
ORGANISM(S): Rattus norvegicus 
2012-03-15 | E-GEOD-32891 | biostudies-arrayexpress
TranscriptomicsGene expression data from acetaminophen-induced toxicity in human hepatic in vitro systems and clinical liver samples
In this study we conducted transcriptomics analyses of: (i) liver samples from patients suffering from acetaminophen-induced acute liver failure (n=3) and from healthy livers (n=2) and (ii) hepatic cell systems exposed to acetaminophen, including their respective vehicle controls. The investigated i...
ORGANISM(S): Homo sapiens 
2015-11-04 | E-GEOD-74000 | biostudies-arrayexpress
ProteomicsHepatic responses of mice and rats to equivalent acetaminophen (APAP) insult – SWATH proteomics
The well-known difference in sensitivity of mice and rats to acetaminophen (APAP) liver injury has been related to differences in the fraction that is bioactivated to the reactive metabolite N-acetyl-p-benzoquinoneimine (NAPQI). Physiologically-based pharmacokinetic modelling was used to identify do...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2023-08-31 | PXD034438 | Pride
Oxidative stress Species differences Swath Liver injury Acetaminophen 
TranscriptomicsTranscription profiling of rat blood after exposure to acetaminophen (APAP) - dose response
Gene expression training data set from rat blood samples exposed to either 150, 1500 or 2500 mg/kg of APAP for 6, 12 or 24 hours. Experiment Overall Design: Male F344/N rats, 10-12 weeks old, were exposed to 0 (vehicle only), 150, 1500 or 2500 mg/kg APAP in 0.5% ethyl cellulose by oral gavage in tw...
ORGANISM(S): Rattus norvegicus 
2008-06-14 | E-GEOD-5593 | biostudies-arrayexpress
TranscriptomicsShifted Metabolic Bias in Livers of Mice Lacking Hepatocytic Thioredoxin Reductase-1 Protects Against Acetaminophen Toxicity
Genetic disruption of thioredoxin reductase 1 protects against acetaminophen (APAP) toxicity. To determine the role of the thioredoxin system on xenobiotic metabolism we challeneged wildtype and txnrd1liver-null mice with acetaminophen. Adult male wildtype and txnrd1 liver-null mice (C57BL6/J) were ...
ORGANISM(S): Mus musculus 
2013-06-08 | E-GEOD-37874 | biostudies-arrayexpress
ProteomicsAcetaminophen Adducts of Rat Liver Microsomal Proteins using LC-MSMS
The metabolism of xenobiotics in the liver can give rise to reactive metabolites that may covalently bind to tissue macromolecules, such as proteins. Determination of proteins which are targeted by reactive metabolites is of importance in drug discovery and molecular toxicology. However, there are d...
ORGANISM(S): Rattus norvegicus (Rat) 
2015-11-04 | PXD002590 | Pride
Napqi High-resolution tandem mass spectrometry Reactive metabolites Acetaminophen Rat liver microsomes Drug-induced liver injury Covalent binding 
ProteomicsProtein Targets of Acetaminophen Covalent Binding in Rat and Mouse Liver Studied by LC-MS/MS
Acetaminophen (N-acetyl-p-aminophenol; APAP) is a mild analgesic and antipyretic used commonly worldwide. Although APAP is considered a safe and effective over-the-counter medication, it is also the leading cause of drug-induced acute liver failure. Its hepatotoxicity has been linked to the covalent...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2022-02-17 | PXD027674 | Pride
Covalent binding Reactive metabolite Napqi Acetaminophen Rat Liver Mouse 
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