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GenomicsMaternal administration of acetaminophen affects meiosis through its metabolite NAPQI targeting SIRT7 in fetal oocytes
Maternal administration of acetaminophen affects meiosis through its metabolite NAPQI targeting SIRT7 in fetal oocytes
PRJNA944103 | ENA
UnknownAcetaminophen-NAPQI hepatotoxicity: a cell line model system genome-wide association study.
Not available
S-EPMC3044203 | biostudies-literature
TranscriptomicsMaternal administration of acetaminophen affects meiosis through its metabolite NAPQI targeting SIRT7 in fetal oocytes
Acetaminophen (APAP) is clinically recommended as analgesic and antipyretic among pregnant women. However, accumulating laboratory evidence shows that the use of APAP during pregnancy may alter fetal development. Since fetal stage is a susceptible window for early oogenesis, we aim to assess the pot...
ORGANISM(S): Mus musculus 
2023-03-18 | GSE227192 | GEO
UnknownAcetaminophen and NAPQI are toxic to auditory cells via oxidative and endoplasmic reticulum stress-dependent pathways.
Not available
S-EPMC4084927 | biostudies-literature
UnknownPhysiologically Based Pharmacokinetic Modeling to Characterize Acetaminophen Pharmacokinetics and N-Acetyl-p-Benzoquinone Imine (NAPQI) Formation in Non-Pregnant and Pregnant Women.
Not available
S-EPMC6994454 | biostudies-literature
ProteomicsUncovering the mechanisms responsible for intravenous paracetamol-induced hypotension
Intravenous (IV) administration of paracetamol (APAP) is well-documented to cause severe hypotension, particularly in critically ill patients. We have previously shown that a metabolite of APAP – N-acetyl-p-benzoquinone imine (NAPQI) – is a potent vasodilator, but whether APAP can be metabolised to ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-20 | PXD047218 | Pride
Napqi Acetaminophen Endothelium Cyp20a1 Myeloperoxidase Paracetamol 
UnknownInvestigating Paracetamol's Role as a Potential Treatment for Parkinson's Disease: Ab Initio Analysis of Dopamine, l-DOPA, Paracetamol, and NAPQI Interactions with Enzymes Involved in Dopamine Metabolism.
Not available
S-EPMC10586264 | biostudies-literature
ProteomicsParacetamol metabolism by endothelial cells – potential mechanism underlying intravenous paracetamol-induced hypotension
We have shown previously that a metabolite of acetaminophen (APAP), N-acetyl-p-benzoquinone imine (NAPQI), is a potent vasodilator, which could underlie the hypotension observed when APAP is administered intravenously. However, it is unknown whether APAP metabolism to NAPQI is possible in the vascul...
ORGANISM(S): Rattus rattus (Black rat) 
2025-05-20 | PXD058085 | Pride
Napqi Acetaminophen Endothelium Cyp20a1 Myeloperoxidase Paracetamol 
TranscriptomicsHepatic responses of mice and rats to equivalent acetaminophen (APAP) insult [rat]
The well-known difference in sensitivity of mice and rats to acetaminophen (APAP) liver injury has been related to differences in the fraction that is bioactivated to the reactive metabolite N-acetyl-p-benzoquinoneimine (NAPQI). Physiologically-based pharmacokinetic modelling was used to identify do...
ORGANISM(S): Rattus norvegicus 
2023-06-20 | GSE205202 | GEO
TranscriptomicsHepatic responses of mice and rats to equivalent acetaminophen (APAP) insult [mouse]
The well-known difference in sensitivity of mice and rats to acetaminophen (APAP) liver injury has been related to differences in the fraction that is bioactivated to the reactive metabolite N-acetyl-p-benzoquinoneimine (NAPQI). Physiologically-based pharmacokinetic modelling was used to identify do...
ORGANISM(S): Mus musculus 
2023-06-20 | GSE205201 | GEO
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