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TranscriptomicsOrigin of a novel CYP20A1 lncRNA through 23 Alu exaptations in the human lineage creates a potential multi-miRNA sponge
Alu repeats contribute to lineage specific novelties in conserved transcriptional regulatory networks. We report for the first time the origin of a multi-miRNA human specific sponge through exaptation of 23 Alu repeats that forms a novel principal isoform of CYP20A1 gene with a 9kb 3’UTR. This 3’UTR...
ORGANISM(S): Homo sapiens 
2021-01-21 | GSE132447 | GEO
GenomicsOrigin of a novel CYP20A1 lncRNA through 23 Alu exaptations in the human lineage creates a potential multi-miRNA sponge
Origin of a novel CYP20A1 lncRNA through 23 Alu exaptations in the human lineage creates a potential multi-miRNA sponge
PRJNA548108 | ENA
GenomicsMicroRNA-592 inhibits the progression of breast cancer through targeting CYP20A1
MicroRNA-592 inhibits the progression of breast cancer through targeting CYP20A1
PRJNA763812 | ENA
UnknownMultiple Alu Exonization in 3'UTR of a Primate-Specific Isoform of CYP20A1 Creates a Potential miRNA Sponge.
Not available
S-EPMC7802813 | biostudies-literature
UnknownCytochrome P450 20A1 in zebrafish: Cloning, regulation and potential involvement in hyperactivity disorders.
Not available
S-EPMC4807407 | biostudies-literature
UnknownOrphan cytochrome P450 20a1 CRISPR/Cas9 mutants and neurobehavioral phenotypes in zebrafish.
Not available
S-EPMC8669017 | biostudies-literature
ProteomicsUncovering the mechanisms responsible for intravenous paracetamol-induced hypotension
Intravenous (IV) administration of paracetamol (APAP) is well-documented to cause severe hypotension, particularly in critically ill patients. We have previously shown that a metabolite of APAP – N-acetyl-p-benzoquinone imine (NAPQI) – is a potent vasodilator, but whether APAP can be metabolised to ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-20 | PXD047218 | Pride
Napqi Acetaminophen Endothelium Cyp20a1 Myeloperoxidase Paracetamol 
ProteomicsParacetamol metabolism by endothelial cells – potential mechanism underlying intravenous paracetamol-induced hypotension
We have shown previously that a metabolite of acetaminophen (APAP), N-acetyl-p-benzoquinone imine (NAPQI), is a potent vasodilator, which could underlie the hypotension observed when APAP is administered intravenously. However, it is unknown whether APAP metabolism to NAPQI is possible in the vascul...
ORGANISM(S): Rattus rattus (Black rat) 
2025-05-20 | PXD058085 | Pride
Napqi Acetaminophen Endothelium Cyp20a1 Myeloperoxidase Paracetamol 
UnknownGene polymorphism of cytochrome P450 significantly affects lung cancer susceptibility.
Not available
S-EPMC6712450 | biostudies-literature
TranscriptomicsMicroRNA-592 inhibits the progression of breast cancer through targeting CYP20A1
Previous studies have shown that miR-592 may play an important role in the development of various cancer types. However, the mechanism of miR-592 in breast cancer progression remains unclear. Functional analysis showed that overexpression of miR-592 significantly inhibited the cell proliferation, cl...
ORGANISM(S): Homo sapiens 
2022-12-22 | GSE184253 | GEO
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