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ProteomicsAnalysis of acetylation stoichiometry suggests that SIRT3 repairs nonenzymatic acetylation lesions
Acetylation is frequently detected on mitochondrial enzymes and the sirtuin deacetylase SIRT3 is thought to regulate metabolism by deacetylating mitochondrial proteins. However, the stoichiometry of acetylation has not been studied and is important for understanding whether SIRT3 regulates or suppre...
ORGANISM(S): Mus musculus (Mouse) 
2015-09-15 | PXD000885 | Pride
Sirt3 Stoichiometry Acetylation Liver 
ProteomicsIntegrated lysine acetylation stoichiometry and proteomics analysis in human cells
Lysine acetylation is a widespread posttranslational modification that targets a large number of biological pathways. Recent studies reveal that lysine acetylation sites exhibit mainly low stoichiometry. Here we explored three sample preparation methods, the use of detergents for the chemical acetyl...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-11-09 | MSV000081704 | MassIVE
ProteomicsIntegrated lysine acetylation stoichiometry and proteomics analysis in human cells
Lysine acetylation is a widespread posttranslational modification that targets a large number of biological pathways. Recent studies reveal that lysine acetylation sites exhibit mainly low stoichiometry. Here we explored three sample preparation methods, the use of detergents for the chemical acetyl...
ORGANISM(S): Homo sapiens (Human) 
2017-09-12 | PXD005903 | Pride
Deacetylase inhibitor Sirt1 Cancer cells Lysine acetylation Stoichiometry Proteomics 
ProteomicsRubisco acetylation stoichiometry in Arabidopsis Thaliana
Multiple studies have shown Rubisco to be subject to Lys-acetylation at various residues; however, conflicting reports exist about the biological significance of these post-translational modifications. One aspect of the Lys-acetylation that has not been addressed in plants generally, or with Rubisco...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2020-09-28 | PXD019268 | Pride
Lys-acetylation Arabidopsis Rubisco 
ProteomicsAnalysis of human acetylation stoichiometry defines mechanistic constraints on protein regulation
Lysine acetylation is a reversible posttranslational modification that occurs at thousands of sites on human proteins. However, the stoichiometry of acetylation remains poorly characterized, and is important for understanding acetylation-dependent mechanisms of protein regulation. Here we provide ac...
ORGANISM(S): Homo sapiens (Human) 
2019-03-12 | PXD009994 | Pride
Acetylation Acetylome Human Hela Stoichiometry 
ProteomicsAcetylation Dynamics and Stoichiometry in Saccharomyces cerevisiae
Quantitative MS analysis of acetylation in yeast using SILAC labeling and MaxQuant. Download Index of Raw files first. We used quantitative mass spectrometry to analyze acetylation dynamics and stoichiometry in Saccharomyces cerevisiae. We found that acetylation accumulated in growth-arrested...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2014-02-03 | PXD000507 | Pride
Acetylation Metabolism Yeast Mitochondria Stoichiometry 
ProteomicsAccurate quantification of site-specific acetylation stoichiometry reveals the impact of sirtuin deacetylase CobB on the E. coli acetylome
We applied SD-SILAC to determine absolute acetylation stoichiometry in exponentially-growing and stationary-phase wild type and sirtuin deacetylase CobB-deficient E. coli. We further assayed stoichiometry in phophotransacetylase (pta) and acetate kinase (ackA) mutant strains in the presence and abse...
ORGANISM(S): Escherichia coli 
2017-03-07 | PXD005757 | Pride
E. coli Sirtuin Acetylation Stoichiometry Cobb 
UnknownAnalysis of acetylation stoichiometry suggests that SIRT3 repairs nonenzymatic acetylation lesions.
Not available
S-EPMC4641529 | biostudies-literature
UnknownAcetylation dynamics and stoichiometry in Saccharomyces cerevisiae.
Not available
S-EPMC4023402 | biostudies-literature
ProteomicsPCK1 acetylation reactivity - stoichiometry
Site-specific reactivity of PCK1 to increasing concentrations of acetyl-CoA. Acetylation stoichiometry is calculated and second-order rate constants are derived.
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
MSV000086210 | MassIVE
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