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MetabolomicsTFAM loss induces nuclear actin assembly upon mDia2 malonylation to promote liver cancer metastasis
The mechanisms underlying cancer metastasis remain poorly understood. Here, we report that TFAM deficiency rapidly and stably induced spontaneous lung metastasis in mice with liver cancer. Interestingly, unexpected polymerization of nuclear actin was observed in TFAM-knockdown HCC cells when cytoske...
2022-06-23 | MTBLS4307 | MetaboLights
TranscriptomicsActin Cytoskeleton Integrates Auxin and Brassinosteroid Signaling in Plants.
We describe a new mutant allele of the ACTIN2 gene with enhanced actin dynamics, displaying a broad array of twisting and bending phenotypes that resemble BR-treated plants. Moreover, auxin transcriptional regulation is enhanced on the mutant background, supporting the idea that shaping actin filame...
ORGANISM(S): Arabidopsis thaliana 
2012-11-21 | E-GEOD-27077 | biostudies-arrayexpress
ProteomicsBistability in the Rac1, PAK and RhoA signalling network is a feature of cell motility.
Dynamic interactions between RhoA and Rac1, members of the Rho small GTPase family, play a vital role in the control of cell migration. Using predictive mathematical modelling and experimental validation in MDA-MB-231 mesenchymal breast cancer cells, we show that Rac1 and RhoA interactions via the P...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080751 | MassIVE
ProteomicsKLF2-induced actin shear fibers control both alignment to flow and JNK signaling in vascular endothelium
The shear stress-induced transcription factor Krüppel-like factor 2 (KLF2) confers anti-inflammatory properties to endothelial cells through inhibition of activator protein 1, presumably by interfering with MAPK cascades. To gain insight into the regulation of these cascades by KLF2, we used antibo...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-19412 | biostudies-arrayexpress
GenomicsReassessment of the roles of coronin proteins as actin effectors and in signalling
Reassessment of the roles of coronin proteins as actin effectors and in signalling
PRJNA1237392 | ENA
TranscriptomicsTranscription profiling by array of human stromal cells cultured with or without 3D BPH-1 prostate epithelial cells
BPH-1 prostate epithelial cells when cultured in Matrigel form 3D acini which closely recapitulate the tissue architecture of the prostate. The presence of primary stroma increases epithelial adhesions and causes changes in morphology. To identify the stromal signals which control actin/cadherin dy...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-MEXP-2657 | biostudies-arrayexpress
ProteomicsProteome analysis of PC12 cells reveals alterations in translation regulation and actin signalling induced by clozapine
Although antipsychotics are routinely used in the treatment of schizophrenia for last decades, their precise mechanism of action is still unclear. In this study we investigated changes in PC12 cells’ proteome under the influence of clozapine, risperidone and haloperidol to identify protein pathways ...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-09-08 | PXD014422 | Pride
Proteome Clozapine Translation Actin signalling Mtor 
TranscriptomicsComparative transcriptome analysis of DFAT cells after the treatment with Y-27632 and the transfection of Mkl1 siRNA
Cellular differentiation is regulated through activation and repression of defined transcription factors. A hallmark of differentiation is a pronounced change in cell shape, which is determined by dynamics of the actin cytoskeleton. In de-differentiated fat (DFAT) cells and 3T3-L1 cells, we showed t...
ORGANISM(S): Mus musculus 
2014-03-28 | E-GEOD-52334 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human dendritic cells from PLOSL patients show abnormalities in pathways of actin bundling and immune response
This study was aimed to identify pathways associated with loss-of-function of the DAP12/TREM2 receptor complex and thus gain insight into pathogenesis of PLOSL (polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy). Transcript profiles of PLOSL patients' DCs showed differenti...
ORGANISM(S): Homo sapiens 
2008-11-06 | E-GEOD-3624 | biostudies-arrayexpress
Proteomics3’,5’-cAMP affects actin cytoskeleton dynamics by direct binding to actin.
Cyclic adenosine monophosphate (3’,5’-cAMP) is a well-characterized and evolutionary conserved second messenger. In contrast to the animal cells, however, the role of 3’,5’-cAMP in plants remains enigmatic. With the exception of cyclic nucleotide-gated ion channels, no plant 3’,5’-cAMP interactors h...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2023-06-02 | PXD019537 | Pride
Camp Actin Cytoskeleton Arabidopsis thaliana Signalling 
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