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ProteomicsTime-course phosphoproteome response during adenovirus type 2 infection
Time-course systematic and quantitative analysis combining TiO2 enrichment and SILAC to investigate changes in the phosphoproteome of Ad2 and IMR-90 cells after adenovirus infection
ORGANISM(S): Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2) Homo sapiens (Human) 
2020-07-03 | PXD009562 | Pride
Mass spectrometry Silac Phosphoproteomics Ad2 Human adenovirus 
ProteomicsMS-based proteomics of Adeonvirus type 2 infected primary human cells
To combat virus infections, which are major human killers, a deeper understanding of how viruses reprogram their hosts to create optimal production of progeny is needed. Most knowledge on the regulation of cellular gene expression during adenovirus infection is derived from studies of mRNA expressio...
ORGANISM(S): Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2) Homo sapiens (Human) 
2016-12-20 | PXD004095 | Pride
Mass spectrometry Deregulation of host cell proteins Adenovirus type 2 infection Silac Imr-90 
ProteomicsTime-resolved proteomics of Adenovirus infected cells
To combat virus infections, which are major human killers, a deeper understanding of how viruses reprogram their hosts to create optimal production of progeny is needed. Most knowledge on the regulation of cellular gene expression during adenovirus infection is derived from studies of mRNA expressio...
ORGANISM(S): Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2) Homo sapiens (Human) 
2018-10-04 | PXD008980 | Pride
Adenovirus type 2 infection Deregulation of host cell proteins Mass spectrometry Silac. Imr-90 
MetabolomicsInfection-Induced Peroxisome Biogenesis Is a Metabolic Strategy for Herpesvirus Replication
Peroxisomes are primarily metabolic organelles with important functions in lipid metabolism, such as fatty acid oxidation and ether phospholipid synthesis (e.g. plasmalogens). Certain viruses, such as human cytomegalovirus (HCMV), hijack organelle functions to facilitate their replication and spread...
2018-10-22 | MTBLS652 | MetaboLights
TranscriptomicsGenome-wide expression profiles of primary human SAECs infected with different adenovirus mutants.
Full title: Genome-wide expression profiles of primary human small airway epithelial cells (SAECs) infected with different adenovirus mutants. Expression arrays were used to analyze global gene expression changes in SAECs infected with either mock, dE1B-55k, or d55k/dORF3 adenovirus at 36 hours post...
ORGANISM(S): Homo sapiens 
2010-08-30 | E-GEOD-20607 | biostudies-arrayexpress
TranscriptomicsKawasaki Disease and Other Febrile Illnesses
ABSTRACT Background. Acute Kawasaki disease (KD) is difficult to distinguish from other acute rash/fever illnesses, in part because the etiologic agent(s) and pathophysiology remain poorly characterized. As a result, diagnosis and critical therapies may be delayed. Methods. We used DNA microarray...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-15297 | biostudies-arrayexpress
MetabolomicsMulti-omics analysis of host airway responses in pediatric Mycoplasma pneumoniae pneumonia reveals potential mechanisms of disease exacerbation caused by co-infection

Respiratory viral co-infections in children with Mycoplasma pneumoniae pneumonia (MPP) are common and cause severe clinical manifestations. However, the exact pathogenic mechanisms of MPP co-infections are still unclear. In this study, we conducted a large-scale clinical analysis of 3,106 MPP pat...

2025-11-25 | MTBLS12635 | MetaboLights
TranscriptomicsA new look at adenovirus splicing
Adenovirus type 2 RNA splicing sites were mapped by using deep cDNA sequencing. The majority of the previously identified splice sites were detected. In addition, novel splicing sites were identified Total RNA obtained from four time stages of human primary lung fibroblast cells IMR-90 infected by a...
ORGANISM(S): Homo sapiens 
2014-03-25 | E-GEOD-54583 | biostudies-arrayexpress
TranscriptomicsExpression profiling of PaTu8988s and PaTu8988t cell lines
We used microarray to look at the genes deregulated in PaTu8988s (adenovirus insensitive) and PaTu8988t (adenovirus sensitive) cell lines PaTu8988s and PaTu8988t are pancreatic cell lines derived from the same patient and show significant responses to oncolytic adenoviruses. The different response t...
ORGANISM(S): Homo sapiens 
2010-01-09 | E-GEOD-14701 | biostudies-arrayexpress
TranscriptomicsEndogenous MicroRNA Activity Is Not Affected Following Infection With MicroRNA Controlled Adenovirus
Replicating viruses have broad applications in biomedicine, notably in cancer virotherapy and in the design of attenuated vaccines, however uncontrolled virus replication in vulnerable tissues can give pathology and often restricts the use of potent strains. Increased knowledge of tissue-selective m...
ORGANISM(S): Mus musculus 
2011-08-19 | E-GEOD-23854 | biostudies-arrayexpress
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