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ProteomicsAdenylyl cyclase 3 deficiency results in the dysfunction of blood-testis barrier during mouse spermiogenesis
Human infertility has become a medical and social health problem globally. Mice deficient in type 3 adenylyl cyclase (AC3), a key enzyme that synthesizes cyclic adenosine monophosphate (cAMP), develop male infertility but its underlying molecular mechanisms are still unknown. Here, we performed labe...
ORGANISM(S): Mus Musculus 
2021-07-19 | PXD027382 |
ProteomicsPharmacological inhibition of mitochondrial soluble adenylyl cyclase in astrocytes causes activation of AMP-activated protein kinase and induces breakdown of glycogen
Astrocytes contain the majority of the brain’s supply of glycogen which has been suggested to play an important role in neuronal synaptic plasticity. This may be mediated by release of glycogen-derived lactate or glutamine supporting neuronal metabolism or via induction of neuronal signaling pathway...
ORGANISM(S): Mus musculus (Mouse) Acyrthosiphon pisum (Pea aphid) 
2021-08-13 | PXD027901 | Pride
Mouse astrocytes Amp-activated protein kinase Energy metabolism Adenylyl cyclase Phosphorylation 
GenomicsTranscriptional changes associated with chemical induction of adenylyl cyclase activity in Mtb
Transcriptional changes associated with chemical induction of adenylyl cyclase activity in Mtb
PRJNA788789 | ENA
ProteomicsThe left ventricular phosphoproteome in mouse with cardiac-specific adenylyl cyclase type 8 overexpression
To study the molecular mechanism of adaption in the mouse with heart-specific overexpression of Adenylyl Cyclase 8 (TGAC8), we performed TMT-labeling mass spectrometry to obtain both total proteome and phosphoproteome of mouse left ventricles. Proteins were extracted from five wild-type and four TGA...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-07-08 | MSV000089850 | MassIVE
ProteomicsAdenylyl cyclase 8, calmodulin - absolute quantification
The aim of this experiment was to absolutely quantify adenylyl cyclase 8 (AC8) and the co-purified interactor calmodulin (CaM) to assess their stoichiometry.
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2024-02-14 | PXD044766 | Pride
Prm Membrane protein Absolute quantification Purified protein 
ProteomicsRetargeting from CR3 to the LFA-1 receptor uncovers the adenylyl cyclase enzymetranslocating segment of Bordetella adenylate cyclase toxin
The Bordetella adenylate cyclase toxinhemolysin (CyaA) and the α-hemolysin (HlyA) of Escherichia coli both belong to the family of cytolytic pore-forming Repeats in ToXin (RTX) cytotoxins. HlyA preferentially binds the αLβ2 integrin LFA-1 (CD11a/CD18) of leukocytes and can promiscuously bind and per...
ORGANISM(S): Escherichia coli Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251) 
2020-05-11 | PXD018789 | Pride
Ac domain translocation Fatty acyl Rtx toxin Acylation Acyltransferase Integrin 
TranscriptomicsTemporal and regional regulation of gene expression by calcium-stimulated adenylyl cyclase activity during fear memory
Mice with the two calcium-stmulated adenylyl cyclase isoforms (AC1 and AC8; DKO mice) knocked-out show conditioned fear memory deficits. We assessed gene expression changes at baseline and several time points after conditioned fear learning to assess transcriptional changes at different stages of l...
ORGANISM(S): Mus musculus 
2010-10-19 | E-GEOD-23008 | biostudies-arrayexpress
UnknownAdenylyl cyclase Rv1625c of Mycobacterium tuberculosis: a progenitor of mammalian adenylyl cyclases.
Not available
S-EPMC125536 | biostudies-literature
ProteomicsThe identification of adenylyl cyclase modulators as potential receptors for 6-nitrodopamine in human-induced pluripotent stem cell (hiPSC)-derived cardiomyocytes and their relevance in heart inotropism
6-Nitrodopamine Q7 Q8 (6-ND Q9 ) has potent positive chronotropic and inotropic effects. At a very low dose, i.e., 10 fM, it causes potentiation of the positive chronotropic effects induced by catecholamines in the rat atria, indicating a distinct mechanism of action. Cyclase-associated proteins (CA...
ORGANISM(S): Homo sapiens (Human) 
2025-09-08 | PXD066711 | Pride
Adrenaline Stromal interaction molecule 1 Cyclase- q10 associated proteins Dopamine Nitro-catecholamine 
UnknownThe Dictyostelium homologue of mammalian soluble adenylyl cyclase encodes a guanylyl cyclase.
Not available
S-EPMC125260 | biostudies-literature
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