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GenomicsDeregulation of PPARβ/δ target genes in tumor-associated macrophages by fatty acid ligands in the ovarian cancer microenvironment - ChIPseq
PPARD and RXR genome wide binding in tumor associated macrophages from serous ovarian carcinoma was characterized.
ORGANISM(S): Homo sapiens 
2015-06-01 | E-MTAB-3166 | biostudies-arrayexpress
TranscriptomicsRNA-seq of murine CD4 T cells after pentanoate treatment compared to untreated control
To analyse the influence of pentanoate on the differentiation of naive CD4 T cells under Th17 inducing conditions, murine CD4 T cells were isolated from spleen and lymphnodes of FIR/TIGER mice (IL-10 (GFP) - Foxp3 (RFP) - Reporter mice). The T cells were kept for 3 days under Th17 inducing condition...
ORGANISM(S): Mus musculus 
2019-01-15 | E-MTAB-6114 | biostudies-arrayexpress
ProteomicsPPARbeta/delta chip-masspectrometry
MDA-MB231-luc2 cells were treated with either L165,041 or PT-S264 and ChIP-MS was performed according to the RIME-protocol (Active Motif Inc.).
ORGANISM(S): Homo sapiens (Human) 
2019-08-06 | PXD012818 | Pride
Agonist Cofactor Ppardelta Inverse agonist Pparbeta Nuclear receptor 
TranscriptomicsDeregulation of PPAR-beta/delta target genes in tumor-associated macrophages by fatty acid ligands in the ovarian cancer microenvironment - RNAseq
The transcriptome of serous ovarian cancer tumor associated macrophages was characterized. Additionally, their transcription response to PPARD agonists and inverse agonists in cell culture was analyzed.
ORGANISM(S): Homo sapiens 
2015-05-31 | E-MTAB-3167 | biostudies-arrayexpress
GenomicsChIP-seq of tumour associated macrophages derived from high grade ovarian serous carcinoma patient ascites
Tumor associated macrophages of one patient were assayed for histone modifications, methylation (MIRA) and CEBP.
ORGANISM(S): Homo sapiens 
2018-08-13 | E-MTAB-6297 | biostudies-arrayexpress
TranscriptomicsThe transcriptional signature of ascites-associated macrophages is linked to interferon signaling and a favorable clinical outcome in a subgroup of ovarian carcinoma patients
mRNA from tumor associated macrophages from high grade serous ovarian carcinoma patients was sequenced.
ORGANISM(S): Homo sapiens 
2017-02-01 | E-MTAB-5199 | biostudies-arrayexpress
TranscriptomicsPPARβ/δ ligand response in monocyte derived macrophages
The PPARD ligand response (agonist and inverse agonist) in monocyte derived macrophages from 3 healthy donors was assesed via RNAseq.
ORGANISM(S): Homo sapiens 
2016-05-13 | E-MTAB-3398 | biostudies-arrayexpress
TranscriptomicsThe transcriptional signature of human ovarian carcinoma macrophages is associated with extracellular matrix reorganization
RNAseq of peritoneal macrophages from patients with non-malignent peritoneal afflictions.
ORGANISM(S): Homo sapiens 
2016-09-27 | E-MTAB-4764 | biostudies-arrayexpress
TranscriptomicsRNA-seq of murine spleen B-cells after pentanoate treatment compared to untreated control
We tested the influence of pentanoate on B cells by treatment of CpG-stimulated B cells in vitro. We isolated naive B cells from FIR/TIGER mice (IL-10 (GFP) - Foxp3 (RFP) - Reporter mice) from spleen. Cells were cultured in presence of 5 µg/ml CpG 2395. 24h after CpG-stimulation, B cells were treate...
ORGANISM(S): Mus musculus 
2019-01-15 | E-MTAB-6115 | biostudies-arrayexpress
TranscriptomicsTranscriptional changes in IMR32 cells upon ISX treatment
IMR32 neuroblastoma cells were treated with ISX, a novel GLI1 inducing HDAC-inhibitor
ORGANISM(S): Homo sapiens 
2021-04-28 | E-MTAB-10249 | biostudies-arrayexpress
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