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TranscriptomicsTime Course of Gene Expression in Rat-1 Fibroblasts Following Alpha-1a Adrenergic Receptor Stimulation with Phenylephrine.
In mammals, increasing evidence supports the generality of cotranscriptional gene regulation and the idea that genetic control often occurs subsequent to RNA polymerase II (Pol II) recruitment. In our recent experiments, we have used Pol II Chromatin Immunoprecipitation (ChIP) to investigate relatio...
ORGANISM(S): Rattus rattus 
2014-08-01 | E-GEOD-59955 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat heart from Lewis strain immunized with a peptide of human alpha1A-adrenergic receptor
Gene expression profiles in hearts of Lewis rats immunized with a peptide of human alpha1A-adrenergic receptor. The pathophysiological relevance of chronic autoantibodies against alpha-1A-adrenergic receptor stimulation in rats was investigated. Lewis rats were immunized using synthesized peptides o...
ORGANISM(S): Rattus norvegicus 
2010-06-15 | E-TABM-725 | biostudies-arrayexpress
ProteomicsAdrenergic Receptor Stimulation Suppresses Metabolism in the Pancreatic β Cell
Glucose-stimulated insulin secretion (GSIS) is suppressed through α-adrenergic receptor stimulation by catecholamines, epinephrine and norepinephrine, in pancreatic β-cells. Previous work has elucidated a bevy of adrenergic regulatory mechanisms beyond traditional Gi-coupled signaling including regu...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-08 | PXD006330 | Pride
Pancreas Mouse Min6 Epinephrine Norepinephrine Insulin Β-cells Catecholamines 
ProteomicsBeta-Adrenergic stimulation of breast cancer MDA-MB-231 and bone tropic MDA-MB-231-BoM 1833 cell line secretome
In this study, we aimed to study the effect of Beta-2 Adrenergic Receptor stimulation on secreted proteins in triple negative breast cancer cell lines. We also wanted to compare protein expression in parental or bone tropic metastatic cell lines and how they respond to adrenergic signaling.
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD030371 | Pride
Human Lc-msms Breast cancer Conditioned medium Secreted 
ProteomicsUnbiased quantitative analysis of the cardiac phosphoproteome in response to acute β-adrenergic receptor stimulation in vivo
We utilised Super-SILAC mouse technology to perform an unbiased, quantitative analysis of the cardiac phosphoproteome in mice acutely treated in vivo with either saline or isoprenaline (ISO), a non-selective β-AR agonist. Using a customized mass spectrometry-based workflow (Figure 1), our study iden...
ORGANISM(S): Mus musculus (Mouse) 
2021-12-30 | PXD025569 | Pride
Phosphoproteome  mass spectrometry  β-adrenergic receptor  silac 
GenomicsBioenergetic responses to β-adrenergic stimulation in beige adipocyte depend on actomyosin driven forces
Bioenergetic responses to β-adrenergic stimulation in beige adipocyte depend on actomyosin driven forces
PRJNA1368784 | ENA
GenomicsSingle cell sequencing of stromal vascular fraction (SVF) under B3-adrenergic agonist stimulation and mature adipocytes under cold exposure and B3-adrenergic agonist stimulation
Single cell sequencing of stromal vascular fraction (SVF) under B3-adrenergic agonist stimulation and mature adipocytes under cold exposure and B3-adrenergic agonist stimulation
PRJNA551597 | ENA
MetabolomicsClenbuterol exerts antidiabetic activity through metabolic reprogramming of skeletal muscle cells
Activation of the sympathetic nervous system causes pronounced metabolic changes that are mediated by multiple adrenergic receptor subtypes. Systemic treatment with β2-adrenergic receptor agonists results in multiple beneficial metabolic effects, including improved glucose homeostasis. To...
2022-08-26 | MTBLS467 | MetaboLights
GenomicsIdentify the genes deregulated by the loss of GPS2 in adipocytes during obesity and metabolic activation (beta-adrenergic stimulation).
Identify the genes deregulated by the loss of GPS2 in adipocytes during obesity and metabolic activation (beta-adrenergic stimulation).
PRJNA437659 | ENA
GenomicsEffect of beta3-adrenergic stimulation on liver gene expression in mice fed either a control diet or a western diet
Effect of beta3-adrenergic stimulation on liver gene expression in mice fed either a control diet or a western diet
PRJNA1175275 | ENA
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