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GenomicsFunctional analysis of AEBP2, a PRC2 Polycomb protein, reveals a Trithorax phenotype in embryonic development and in ES cells
The Polycomb repressive complexes PRC1 and PRC2 are key mediators of heritable gene silencing in multicellular organisms. Here we characterize AEBP2, a known PRC2 cofactor which, in vitro, has been shown to stimulate PRC2 activity. We show that AEBP2 localises specifically to PRC2 target loci, incl...
ORGANISM(S): Mus musculus 
2016-08-02 | E-GEOD-83082 | biostudies-arrayexpress
GenomicsOpposing functions of AEBP2 isoforms fine-tune PRC2 catalytic activity
Opposing functions of AEBP2 isoforms fine-tune PRC2 catalytic activity
PRJNA1365306 | ENA
GenomicsAuto-inhibition of PRC2 by the broadly expressed long isoform of AEBP2.
Auto-inhibition of PRC2 by the broadly expressed long isoform of AEBP2.
PRJNA899502 | ENA
UnknownAebp2 as an epigenetic regulator for neural crest cells.
Not available
S-EPMC3176318 | biostudies-literature
UnknownRetrotransposon-derived promoter of Mammalian Aebp2.
Not available
S-EPMC4411029 | biostudies-literature
UnknownAEBP2 as a potential targeting protein for Polycomb Repression Complex PRC2.
Not available
S-EPMC2685092 | biostudies-literature
UnknownAEBP2 as a transcriptional activator and its role in cell migration.
Not available
S-EPMC4314425 | biostudies-literature
ProteomicsAuto-inhibition of PRC2 by the broadly expressed long isoform of AEBP2.
Polycomb Repressive Complex 2 (PRC2) is an essential chromatin regulator responsible for mono-, di- and tri- methylating H3K27. Control of PRC2 activity is a critical process in development and disease. While PRC2 is inhibited in germinal cells, no inhibitory cofactor has been identified in somatic ...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-26 | PXD053693 | Pride
Cryo-em. Jarid2 Embryonic stem cells Prc2.2 Polycomb Suz12 Trithorax Aebp2 
GenomicsAEBP2’s roles in cell migration and Polycomb Repressive Complex 2 (PRC2)
Aebp2 encodes a zinc finger protein that is associated with the Polycomb Repressive Complex 2 (PRC2). The alternative promoters and protein isoforms of Aebp2 have been characterized in this study. Aebp2 is controlled through three alternative promoters, deriving three different transcripts which enc...
ORGANISM(S): Mus musculus 
2015-10-23 | GSE62680 | GEO
UnknownJARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other histone modifications.
Not available
S-EPMC7993630 | biostudies-literature
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