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TranscriptomicsThe Polycomb Group Protein Suz12 Is Required for Embryonic Stem Cell Differentiation
Polycomb group (PcG) proteins form multiprotein complexes, called Polycomb repressive complexes (PRCs). PRC2 contains the PcG proteins EZH2, SUZ12, and EED and represses transcription through methylation of lysine (K) 27 of histone H3 (H3). Suz12 is essential for PRC2 activity and its inactivation r...
ORGANISM(S): Mus musculus 
2011-08-11 | E-GEOD-31354 | biostudies-arrayexpress
ProteomicsSUZ12 immunoprecipitation followed by PRM of SUZ12 peptides to identify alternatively spliced isoforms of SUZ12 at the protein level.
Alternative splicing of SUZ12 exon 4 is predicted to generate two alternative isoforms differing by the inclusion or exclusion of 69 nucleotides in exon 4, which we named SUZ12-long (SUZ12-L) and SUZ12-short (SUZ12-S) respectively. At the protein level SUZ12 exon 4 encodes 23 amino acids (aa 129–152...
ORGANISM(S): Mus musculus (Mouse) 
2024-03-18 | PXD046742 | Pride
Exon As Ip Prc2 Mescs Alternative splicing Prm. Escs Suz12 Polycomb 
ProteomicsSUZ12 immunoprecipitation followed by protein indentification via mass spectrometry (SUZ12 IP-MS) in mESCs of SUZ12 WT, delta exon 4, KO, and KO rescues with SUZ12-L and SUZ12-S
Suz12 exon 4 encodes 23 amino acids (aa 129–152 in SUZ12-L) that partially overlap with the WD-binding domain 1 (WDB1, 110–145). We reasoned that exon 4 skipping might alter the structure of SUZ12 and, possibly, PRC2 composition. To explore this possibility, we generated ESCs that lack the Suz12 exo...
ORGANISM(S): Mus musculus (Mouse) 
2024-03-18 | PXD046660 | Pride
Flag-tag Rescues Ko Ip Prc2 Interactions Mescs Escs Suz12 Polycomb 
ProteomicsHistone post translational modification mass sprectrometry SUZ12 exon 4 cell lines
We investigate the contribution of each SUZ12 isoform on PRC2 activity on chromatin using our different ESC lines. As an additional comparison for ∆ex4 cells (SUZ12-S), we included an ESC clone in which an unsuccessful CRISPR editing event resulted in a mutant allele with nearly constitutive splicin...
ORGANISM(S): Mus musculus (Mouse) 
2024-03-18 | PXD046640 | Pride
Ptms Ko Histones Prc2 Mescs Escs Suz12 Dda Polycomb 
GenomicsTranscriptome of JAZF1-SUZ12 translocation
Transcriptome of JAZF1-SUZ12 translocation
PRJNA807168 | ENA
TranscriptomicsTranscription profiling of mouse G1ME cells following retroviral infection and shRNA-mediated knock-down of Suz12 and Ezh2
Suz12 in hematopoiesis II. Retroviral Infection and shRNA-mediated knock-down of Suz12 and Ezh2 in mouse G1ME cells.
ORGANISM(S): Mus musculus 
2008-07-03 | E-TABM-396 | biostudies-arrayexpress
GenomicsH3K27me3 and SUZ12 CUT&RUN in K562 cells depleted of CRAMP1 or SUZ12
H3K27me3 and SUZ12 CUT&RUN in K562 cells depleted of CRAMP1 or SUZ12
PRJNA1159301 | ENA
GenomicsH3K27me3 and SUZ12 CUT&Tag in K562 cells depleted of CRAMP1 or SUZ12
H3K27me3 and SUZ12 CUT&Tag in K562 cells depleted of CRAMP1 or SUZ12
PRJNA1159292 | ENA
TranscriptomicsExpression data from Control or ShSuz12 rat Intestinal epithelial cells IEC-6
Polycomb-group proteins form multimeric protein complexes involved in transcriptional silencing. The Polycomb Repressive complex 2 (PRC2) contains the Suppressor of Zeste-12 protein (Suz12) and the histone methyltransferase Enhancer of Zeste protein-2 (Ezh2). This complex, catalyzing the di- and tri...
ORGANISM(S): Rattus norvegicus 
2014-08-02 | E-GEOD-60003 | biostudies-arrayexpress
UnknownThe expression and role of SUZ12 in lung adenocarcinoma.
Not available
S-EPMC11471883 | biostudies-literature
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