ABSTRACT The voltage-gated calcium channel CaV2.2 is predominantly located in neuronal synapses, where it plays a role in pain signaling and neurotransmitter release. Furthermore, CaV2.2 is important during early central nervous system development, as it is subsequently replaced by other calcium ...
Neuropsychiatric conditions impose a substantial global burden, yet the contribution of microbiota–gut–brain communication to their biology remains difficult to interpret in humans. Metagenomic studies could help characterize microbial neuroactive potential, but such analyses remain constrained b...
Gut microbiome dysbiosis is often associated with immune-mediated diseases. Here, we used germ-free (GF) mice, the synthetic minimal consortium OMM12, and specific pathogen-free (SPF) mice to dissect the causal influence of the microbiome on anti-viral immunity. The lack of microbial diversity af...