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MetabolomicsGut microbiota-modulated glutamic acid rejuvenates the quality of oocytes deteriorated by advanced reproductive age

The gut microbiota plays a vital role in maintaining the physiological function of host health and the pathogenesis of various diseases. However, its relationship with maternal age-associated decline in oocyte quality remains elusive. Here, we report that establishment of gut microbiota from youn...

2026-05-07 | MTBLS14062 | MetaboLights
ProteomicsCordycepin Delays Postovulatory Aging of Mammalian Oocytes through Inhibition of Maternal mRNAs Degradation via DCP1A Polyadenylation Suppression
Postovulatory aging leads to the decline in oocyte quality and subsequent impairment of embryonic development, thereby reducing the success rates of assisted reproductive technology (ART). Nevertheless, potential preventative strategies to improve aging oocytes quality and the associated underlying ...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD042600 | Pride
Aging oocytes Cordycepin 
MetabolomicsUridine restores oocyte quality and mitigates female reproductive aging by inhibition of ferroptosis in mice

Advanced maternal age is a key factor in female infertility, primarily due to declines in ovarian reserve and oocyte quality. However, the metabolic mechanisms underlying reproductive aging are still poorly understood. Here, we show that uridine levels in the plasma and ovaries of aged mice are s...

2026-03-03 | MTBLS13957 | MetaboLights
TranscriptomicsIncreased expression of BubR1 protects against aneuploidy in aging oocytes and extends reproductive lifespan
Chromosome aneuploidy increases in oocytes with maternal age, and is considered the leading cause for the increased incidence of infertility, miscarriage, and birth defects. Using mRNA-Sequencing of oocytes from 12 month old mouse versus 3 month young mouse, we identified a spindle assembly checkpoi...
ORGANISM(S): Mus musculus 
2014-05-10 | E-GEOD-57482 | biostudies-arrayexpress
TranscriptomicsMassive decrease of maternal polyA mRNA upon post-ovulatory aging in Xenopus tropicalis
We used microarrays to detail the global gene expression changes following aging of oocytes We compared fresh oocytes with post-ovulatory aged oocytes by microarray analysis
ORGANISM(S): Xenopus (Silurana) tropicalis 
2011-03-29 | E-GEOD-21109 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse metaphase II oocytes collected from 5-6 week old mice with those collected from 40-42 week old mice
Decreasing oocyte competence with maternal aging is a major factor in human infertility. To investigate the age-dependent molecular changes in a mouse model, we compared the expression profiles of metaphase II oocytes collected from 5-6 week old mice with those collected from 40-42 week old mice usi...
ORGANISM(S): Mus musculus 
2004-09-01 | E-MEXP-150 | biostudies-arrayexpress
TranscriptomicsMaternal age effect on mouse oocytes: new biological insight from proteomic analysis
The long-standing view of 'immortal germ line versus mortal soma' poses a fundamental question in biology concerning how oocytes age in molecular terms. A mainstream hypothesis is that maternal aging of oocytes has its roots in gene transcription. Investigating the proteins resulting from mRNA trans...
ORGANISM(S): Mus musculus 
2014-04-15 | E-GEOD-42959 | biostudies-arrayexpress
TranscriptomicsAge-associated alteration of gene expression patterns in mouse oocytes
Decreasing oocyte competence with maternal aging is a major factor in human infertility. To investigate the age-dependent molecular changes in a mouse model, we compared the expression profiles of metaphase II oocytes collected from 5-6 week old mice with those collected from 40-42 week old mice us...
ORGANISM(S): Mus musculus 
2010-06-06 | E-GEOD-1646 | biostudies-arrayexpress
ProteomicsGrowth hormone supplementation reduces aneuploidy and improves the quality of oocytes by activating ERK1/2 pathway in aged mice
The decline in oocyte quality is a limiting factor of female fertility; however, strategies to maintain the oocyte quality of aged women are not available. In this study, we showed that growth hormone (GH) supplementation in vivo not only alleviated the decline in oocyte number caused by aging, but ...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-20 | PXD039147 | Pride
Aneuploidy Oocyte quality Aged oocytes Growth hormone 
ProteomicsExploration on the Mechanism of Decreased Quality of Aging Oocytes After Ovulation
Decreased oocyte developmental potential is an important factor affecting fertility and embryonic development. Increasingly evidence is suggested that the decline in oocyte quality caused by aging after in vitro ovulation is a limiting factor affecting the development of assisted reproductive techno...
ORGANISM(S): Mus Musculus 
2022-11-23 | PXD038293 |
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