Sort   by:  
 Page size 
ProteomicsA phosphoproteomic comparison of B-RAFV600E and MKK1/2 inhibitors in melanoma cells, part 1
To provide insight into the molecular nature of the clinical responses seen with MAPK pathway inhibition in melanoma, we used quantitative mass spectrometry to characterize the inhibitor-dependent phosphoproteome of human melanoma cells treated with the B-RAFV600E inhibitor PLX4032 (vemurafenib) and...
ORGANISM(S): Homo sapiens (Human) 
2016-02-25 | PXD001560 | Pride
Human Melanoma Azd6244 Silac Plx4032 
TranscriptomicsMolecular insights into mild exercise-induced enhancement of spatial memory and neurogenesis: a DNA microarray approach
Many studies have reported on beneficial aspects of running to improve hippocampus-related spatial memory and promote neuroplastic changes like adult hippocampal neurogenesis (AHN). Such research has also revealed molecular factors associated with molecular signaling by BDNF and IGF-I leading to CRE...
ORGANISM(S): Rattus norvegicus 
2014-04-05 | E-GEOD-45813 | biostudies-arrayexpress
ProteomicsCooperative polarization of MCAM/CD146 and ERM family proteins in melanoma
The WRAMP structure is a protein network associated with tail-end actomyosin contractility, membrane retraction, and directional persistence during cell migration. A marker of WRAMP structures is melanoma cell adhesion molecule (MCAM) which dynamically polarizes to the cell rear. However, factors th...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD047722 | Pride
Wnt5a Wramp Mcam Erm 
ProteomicsA phosphoproteomic comparison of B-RAFV600E and MKK1/2 inhibitors in melanoma cells, part 2
. To provide insight into the molecular nature of clinical responses to B-RAF(V600E) and MKK1/2 inhibition, we used quantitative mass spectrometry to characterize the inhibitor-dependent phosphoproteome of human melanoma cells treated with the B-RAF(V600E) inhibitor PLX4032 (vemurafenib) and the MKK...
ORGANISM(S): Homo sapiens (Human) 
2016-02-25 | PXD001563 | Pride
Azd6244 Melanoma Silac Plx4032 
ProteomicsSpecificity of phosphorylation responses to MAP kinase pathway inhibitors in melanoma cells, experiment 2 of 2
We used phosphoproteomics to compare the responses of the ERK1/2 inhibitors, SCH772984 and GDC0994, and the MKK1/2 inhibitor, trametinib. These are compared with responses to the MKK1/2 inhibitor, selumetinib (AZD6244), previously measured by our lab in the same metastatic melanoma cell line. In thr...
ORGANISM(S): Homo sapiens (Human) 
2018-01-02 | PXD007621 | Pride
Human Melanoma Silac Selumetinib Trametinib Gdc0994 Sch772984 
ProteomicsSpecificity of phosphorylation responses to MAP kinase pathway inhibitors in melanoma cells, experiment 1 of 2
We used phosphoproteomics to compare the responses of the ERK1/2 inhibitors, SCH772984 and GDC0994, and the MKK1/2 inhibitor, trametinib. These are compared with responses to the MKK1/2 inhibitor, selumetinib (AZD6244), previously measured by our lab in the same metastatic melanoma cell line. In thr...
ORGANISM(S): Homo sapiens (Human) 
2018-01-02 | PXD007620 | Pride
Human Melanoma Silac Selumetinib Trametinib Gdc0994 Sch772984 
UnknownThe p38β mitogen-activated protein kinase possesses an intrinsic autophosphorylation activity, generated by a short region composed of the α-G helix and MAPK insert.
Not available
S-EPMC4156038 | biostudies-literature
ProteomicsFunctional and molecular dissection of viral lncRNAs throughout HCMV life cycle
Small, compact genomes confer a selective advantage to viruses, yet human cytomegalovirus (HCMV) expresses the long non-coding RNAs (lncRNAs) RNA1.2, RNA2.7, RNA4.9, and RNA5.0. These lncRNAs account for majority of the viral transcriptome, but their functions remain largely unknown. Here, we showed...
ORGANISM(S): Homo sapiens (Human) 
2022-11-14 | PXD034587 | Pride
Hcmv Rna modification Lncrna 
UnknownProposal of a New Risk Score for Patients Treated with Transarterial Chemoembolization due to Recurrent Hepatocellular Carcinoma after Curative Resection: A Multicenter Study.
Not available
S-EPMC7366139 | biostudies-literature
TranscriptomicsSex Differences in Nucleus Accumbens Transcriptome Profiles Associated with Susceptibility versus Resilience to Subchronic Variable Stress
Depression and anxiety disorders are more prevalent in females, but the majority of research in animal models, the first step in finding new treatments, has focused predominantly on males. Here we report that exposure to subchronic variable stress (SCVS) induces depression-associated behaviors in fe...
ORGANISM(S): Mus musculus 
2016-08-04 | E-GEOD-85136 | biostudies-arrayexpress
Sort   by:  
 Page size