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ProteomicsInterruption of p53-MDM2 Interaction by Nutlin-3a in Human Lymphoma Cell Models Initiates a Cell-Dependent Global Effect on Transcriptome and Proteome Level
In most lymphomas, p53 signaling pathway is inactivated by various mechanisms independent to p53 gene mutations or deletions. In many cases, p53 function is largely regulated by alterations in the protein abundance levels by the action of E3 ubiquitin-protein ligase MDM2, targeting p53 to proteasome...
ORGANISM(S): Homo sapiens (Human) 
2023-07-30 | PXD009290 | Pride
Proteomics Lymphoma Mdm2 Apoptosis Transcriptomics Systems biology Nutlin 3a P53 
ProteomicsTissue-infiltrating macrophages mediate an exosome-based metabolic reprogramming upon DNA damage
DNA damage and metabolic disorders are intimately linked with premature disease onset but the underlying mechanisms remain poorly understood. Here, we show that persistent DNA damage accumulation in tissue-infiltrating macrophages carrying an ERCC1-XPF DNA repair defect (Er1F/-) riggers Golgi disper...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-06 | PXD015727 | Pride
Proteome discoverer Mouse Label-free Nlc-ms/ms Scaffold Orbitrap 
ProteomicsIdentify the protein partners of Ercc1 in DNA damage progeria in MEFs
ERCC1 is a DNA endonuclease participating in the Nucleotide Excision Repair (NER) pathway. Its functionality is related to XPF; the two proteins work as a heterodimer to incise the 5 of a 30-mer that contains the damaged nucleotide and remove the fragment together with XPG. Apart from NER deficiency...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-04 | PXD017063 | Pride
Mefs Xpf Proteomics In vivo biotinylation tagging Ercc1 Dna damage progeria Mouse Protein-protein interactions 
ProteomicsERCC1-XPF Cooperates with CTCF and the Cohesin to Facilitate the Developmental Silencing of Imprinted Genes
Inborn defects in DNA repairare associated with complex developmental disorders whose causal mechanisms are poorly understood. Using an in vivo biotinylation tagging approach in mice, we show that the nucleotide excision repair (NER) structure-specific endonuclease ERCC1-XPF complex interacts with t...
ORGANISM(S): Mus musculus (Mouse) 
2017-04-04 | PXD005897 | Pride
Levers Ap-ms In vivo biotinylation tagging Mouse Ner Label-free Ercc1-xpf 
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