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ProteomicsBipolar and schizophrenia risk gene AKAP11 encodes an autophagy receptor coupling the regulation of PKA kinase network homeostasis to synaptic transmission
AKAP11 deficiency is associated with autophagy-regulated PKA and neuronal activity in mouse brains. We hypothesized that the differentially expressed proteins (DEPs) and phospho-proteins (pDEPs) in AKAP11 conditional KO mice and human iPSC-induced neurons (iNs) could be identified as potential AKAP1...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-12-08 | PXD067156 | Pride
Mouse models Synaptic transmission Er-resident autophagy-related proteins vapa/b Bipolar disorder (bd) Protein kinase a (pka) Pka-ri. Electrophysiology Akap11 Multi-omics Cell biology Schizophrenia (scz) Human induced neurons Gsk3a/b Sphkap 
UnknownSchizophrenia-Related Synaptic Dysfunction and Abnormal Sensorimotor Gating in Akap11-Deficient Mice.
Not available
S-EPMC12809822 | biostudies-literature
UnknownMouse mutants in schizophrenia risk genes GRIN2A and AKAP11 show EEG abnormalities in common with schizophrenia patients.
Not available
S-EPMC10011509 | biostudies-literature
GenomicsAkap11 is a positive regulator of osteogenesis in mouse osteoblastic cell line MC3T3-E1
Akap11 is a positive regulator of osteogenesis in mouse osteoblastic cell line MC3T3-E1
PRJNA562822 | ENA
UnknownLithium partially rescues gene expression and enhancer activity from heterozygous knockout of AKAP11 while inducing novel differential changes.
Not available
S-EPMC12572197 | biostudies-literature
GenomicsLithium partially rescues gene expression and enhancer activity from heterozygous knockout of AKAP11 while inducing novel differential changes [ChIP-Seq]
Lithium partially rescues gene expression and enhancer activity from heterozygous knockout of AKAP11 while inducing novel differential changes [ChIP-Seq]
PRJNA1228066 | ENA
GenomicsLithium partially rescues gene expression and enhancer activity from heterozygous knockout of AKAP11 while inducing novel differential changes [RNA-Seq]
Lithium partially rescues gene expression and enhancer activity from heterozygous knockout of AKAP11 while inducing novel differential changes [RNA-Seq]
PRJNA1228056 | ENA
UnknownBipolar and schizophrenia risk gene AKAP11 encodes an autophagy receptor coupling the regulation of PKA kinase network homeostasis to synaptic transmission.
Not available
S-EPMC12663438 | biostudies-literature
GenomicsBipolar and schizophrenia risk gene AKAP11 encodes an autophagy receptor coupling the regulation of PKA kinase network homeostasis to synaptic transmission
Bipolar and schizophrenia risk gene AKAP11 encodes an autophagy receptor coupling the regulation of PKA kinase network homeostasis to synaptic transmission
PRJNA1301334 | ENA
UnknownAKAP11 gene polymorphism is associated with bone mass measured by quantitative ultrasound in young adults.
Not available
S-EPMC6036159 | biostudies-literature
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