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ProteomicsThe inflammation repressor TNIP1 is degraded by selective autophagy in a LIR-dependent manner upon TLR3 activation
In the project « The inflammation repressor TNIP1 is degraded by selective autophagy in a LIR-dependent manner upon TLR3 activation » Jianwen Zhou, Nikoline Lander Rasmussen, Vyacheslav Akimov, Blagoy Blagoev, Trond Lamark, Terje Johansen and Jörn Dengjel performed MS-based proteomics to study the f...
ORGANISM(S): Homo sapiens (Human) 
2022-08-07 | PXD027163 | Pride
Lc-msms Inflammation Silac Human 
ProteomicsDeubiquitinating enzymes and the proteasome regulate unique sets of ubiquitin substrates.
The ubiquitin-proteasome axis has been extensively explored at a system-wide level, but the impact of deubiquitinating enzymes (DUBs) on the ubiquitinome remains largely unknown. Using UbiSite technology and inhibitors, we have compared the contributions of the proteasome and DUBs on the ubiquitinom...
ORGANISM(S): Homo sapiens (Human) 
2022-05-23 | PXD030644 | Pride
Dia The ubiquitin-proteasome system Lc-ms/ms 
ProteomicsThe placenta has an active role in maintaining fetal homeostasis following maternal immune activation
Activation of the maternal immune system during pregnancy can fetal development, which can lead to postnatal susceptibility to a wide range of diseases, including cardiovascular, metabolic and psychiatric disorders. During maternal immune activation (MIA), the maternal body must balance its ressourc...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-13 | PXD039402 | Pride
Lc-ms/ms Mouse placenta Fetal liver Phosphoproteomics 
ProteomicsMagnitude of ubiquitination determines the fate of activated epidermal growth factor receptor and downstream cellular effects
Receptor tyrosine kinases (RTK) bind growth factors and are critical for cell proliferation and differentiation. Their dysregulation leads to a loss of growth control, often resulting in cancer. Epidermal growth factor receptor (EGFR) is the prototypic RTK and can bind several ligands exhibiting dis...
ORGANISM(S): Homo sapiens (Human) 
2022-05-31 | PXD019621 | Pride
Mathematical modelling Proteomics Mass spectrometry Tgf Rtk Egf Epiregulin Signaling Aqua Egfr Ubiquitin 
ProteomicsDissection of IL-2 and IL-15 signaling pathways
The aim of this study was to compare the signaling cascades initiated by the two closely related cytokines IL-2 and IL-15. Considering the relevance of protein tyrosine phosphorylation in signal transduction, in order to quantify changes in protein phosphorylation in response to IL-2 and IL-15, we c...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080767 | MassIVE
ProteomicsCharacterization of receptor-associated protein complex assembly in Interleukin (IL)-2- and IL-15-activated T-lymphocytes
Despite extensive investigation, it remains a paradox that IL-2 and IL-15 can differentially modulate the immune response using the same signaling receptors. In our previous work, we dissected the phosphotyrosine-driven signaling cascades triggered by both cytokines in Kit225 T-cells unveiling subtl...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080850 | MassIVE
ProteomicsNuclear phosphoproteomics analysis of resting and IL-2-stimulated T lymphocytes
The aim of the present project was to study in detail the site-specific phosphorylation events occurring both in resting as well as in T lymphocytes stimulated with IL-2 for five minutes. For that purpose we combined SILAC-based quantitative mass spectrometry analysis with phosphopeptide enrichment ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080773 | MassIVE
ProteomicsHs_HESC_Phospho_Silac_NCM_2r
hESCs cultured treated with nonconditioned medium (NCM) for 0min, 1hr or 24hr.
ORGANISM(S): Homo Sapiens (human) 
2011-12-31 | PAe005298 | PeptideAtlas
ProteomicsHs_HESC_Phospho_Silac_PMA_2
hESCs cultured treated with PMA for 0min, 1hr or 24hr
ORGANISM(S): Homo Sapiens (human) 
2011-12-31 | PAe005235 | PeptideAtlas
ProteomicsHs_HESC_Phospho_Silac_PMA_1r
hESCs cultured treated with PMA for 0min, 30min or 6hr
ORGANISM(S): Homo Sapiens (human) 
2011-12-31 | PAe005282 | PeptideAtlas
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