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ProteomicsFAM111A regulates replication origin activation and cell fitness
FAM111A is a replisome associated protein and dominant mutations within its trypsin-like peptidase domain are linked to severe human developmental syndrome, the Kenny-Caffey syndrome. However, FAM111A functions remain unclear. Here, we show that FAM111A facilitates efficient activation of DNA replic...
ORGANISM(S): Homo sapiens (Human) 
2023-10-03 | PXD044180 | Pride
Dna replication Developmental syndrome Peptidase Genome stability 
ProteomicsRIF1 orchestrates a multi-step restoration of post-replicative H3K9me3
DNA replication causes the dilution of parental histones along with their specific post-translational modifications. The kinetics of restoring these marks on newly incorporated histones dictate how quickly genomic domains regain their epigenetic identity after replication. H3K9me3 is restored extrem...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-08 | PXD066722 | Pride
Dna replication Tmt Lc-ms 
ProteomicsProteomic profiling reveals distinct phases to the restoration of chromatin following DNA replication
Chromatin organization must be maintained during cell proliferation to preserve cellular identity and genome integrity. However, DNA replication results in transient displacement of DNA bound proteins, and it is unclear how they regain access to newly replicated DNA. Using quantitative MS-based prot...
ORGANISM(S): Homo sapiens (Human) 
2023-02-02 | PXD038113 | Pride
Proteomics Lc-ms Tmt 
ProteomicsProteomic profiling reveals distinct phases to the restoration of chromatin following DNA replication
Chromatin organization must be maintained during cell proliferation to preserve cellular identity and genome integrity. However, DNA replication results in transient displacement of DNA bound proteins, and it is unclear how they regain access to newly replicated DNA. Using quantitative MS-based prot...
ORGANISM(S): Homo sapiens (Human) 
2023-02-02 | PXD038376 | Pride
Tmt Proteomics 
ProteomicsRNA polymerase II acts to promote the organization of chromatin following DNA replication
In mammals, following the passage of the replisome, nucleosomes lose their defined positioning and transcription contributes to their re-organisation. However, whether transcription plays a greater role in the organization of chromatin following DNA replication remains unclear. The data uploaded are...
ORGANISM(S): Homo sapiens (Human) 
2024-02-14 | PXD040888 | Pride
Tmt Proteomics Dna replications 
ProteomicsRNA polymerase II acts to promote the organization of chromatin following DNA replication
In mammals, following the passage of the replisome, nucleosomes lose their defined positioning and transcription contributes to their re-organisation. However, whether transcription plays a greater role in the organization of chromatin following DNA replication remains unclear. By performing iPOND-T...
ORGANISM(S): Homo sapiens (Human) 
2024-02-14 | PXD046546 | Pride
Tmt Proteomics Dna replications 
ProteomicsRNA polymerase II promotes the organization of chromatin following DNA replication
Understanding how chromatin organisation is duplicated on the two daughter strands is a central question in epigenetics. In mammals, following the passage of the replisome, nucleosomes lose their defined positioning and transcription contributes to their re-organisation. However, whether transcripti...
ORGANISM(S): Homo sapiens (Human) 
2024-02-14 | PXD046514 | Pride
Tmt Proteomics Dna replications 
ProteomicsProteomic profiling reveals distinct phases to the restoration of chromatin following DNA replication
Chromatin organization must be maintained during cell proliferation to preserve cellular identity and genome integrity. However, DNA replication results in transient displacement of DNA bound proteins, and it is unclear how they regain access to newly replicated DNA. Using quantitative MS-based prot...
ORGANISM(S): Homo sapiens (Human) 
2023-02-02 | PXD035489 | Pride
Chromatin Dna repair Access to dna Cell cycle Restoration Heterochromatin Euchromatin Transcription factors Dna replication Propagation 
ProteomicsProteomic profiling reveals distinct phases to the restoration of chromatin following DNA replication
Chromatin organization must be maintained during cell proliferation to preserve cellular identity and genome integrity. However, DNA replication results in transient displacement of DNA bound proteins, and it is unclear how they regain access to newly replicated DNA. Using quantitative MS-based prot...
ORGANISM(S): Homo sapiens (Human) 
2023-02-02 | PXD036236 | Pride
Tmt Proteomics 
ProteomicsReplication-Associated Chromatin assembly promotes Pluripotency Exit and Differentiation
We map the proteomic composition of newly replicated nascent and mature chromatin in induced pluripotent stem (iPS) cells and during their differentiation along the presomitic mesoderm (PSM) pathway. We identify hundreds of proteins whose association with the replisome is significantly different bet...
ORGANISM(S): Homo sapiens (Human) 
2026-10-16 | PXD059790 | Pride
Chromatin Proteomics Tmt Ipond 
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