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MetabolomicsProtein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase

Metabolic networks are interconnected and influence diverse cellular processes. The protein-metabolite interactions that mediate these networks are frequently low affinity and challenging to systematically discover. We developed mass spectrometry integrated with equilibrium dialysis for the disco...

2023-08-07 | MTBLS7237 | MetaboLights
ProteomicsCrystalline cellulose hydrolysis in microbial communities via actinobacterial glycoside hydrolase family 12
Proteomic data from supernatants from thermophilic cellulolytic microbial communities, for the identification of specific hydrolases from Thermobispora bispora related actinobacterium.
ORGANISM(S): environmental samples 
2016-08-25 | PXD004204 | Pride
Proteomics Metaproteome Hydrolases Actinobacterium 
TranscriptomicsNascent elongating transcript sequencing (NET-seq) for Escherichia coli and Bacillus subtilis reveals a consensus pause sequence enriched at translation start sites.
Transcription by RNA polymerase (RNAP) is interrupted by pauses that play diverse regulatory roles. Although individual pauses have been studied in vitro, the determinants of pauses in vivo and their distribution throughout the bacterial genome remain unknown. Using nascent transcript sequencing we ...
ORGANISM(S): Bacillus subtilis 
2014-05-05 | E-GEOD-56720 | biostudies-arrayexpress
ProteomicsSurface proteomics reveals CD72 as a target for in vitro-evolved nanobody-based CAR-T cells in refractory B-cell malignancies
Alternate strategies are needed for B-cell malignancy patients relapsing after CD19-targeted immunotherapy. Here, integrated cell surface proteomics and epigenetic analysis initially revealed CD72 as an optimal target for poor-prognosis MLL-rearranged B-ALL, which we further found to be expressed wi...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD016800 | Pride
B-all Cell surface Cd72 
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