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ProteomicsFP-biotin enrichment of serine hydrolases in Enterococcus faecium
In our study, we employed activity-based protein profiling (ABPP), a technique that uses specialized inhibitors to identify active serine hydrolases in different strains of E. faecium (clade A1 and A2) and E. lactis under various growth conditions. Serine hydrolases, a large and diverse family of en...
ORGANISM(S): Enterococcus faecium Bacteria 
2024-06-22 | PXD048798 | Pride
Lc-msms Enterococcus faecium Activity-based protein profiling Fp-biotin Serine hydrolases 
GenomicsFunctional exploration of novel glycoside hydrolases in Fervidibacter sacchari PD1T
Functional exploration of novel glycoside hydrolases in Fervidibacter sacchari PD1T
PRJNA1051158 | ENA
ProteomicsAIG1 and ADTRP are endogenous FAHFA hydrolases
Fatty acid esters of hydroxy fatty acids (FAHFAs) are a newly discovered class of signaling lipids with anti-inflammatory and anti-diabetic activities. However, the endogenous regulation of FAHFAs remains a pressing but unanswered question. Here, we find that androgen- induced gene 1 (AIG1) and andr...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-09 | PXD017539 | Pride
Threonine hydrolase Metabolism Adtrp Lipid Enzyme inhibitor Fahfa Aig1 Diabetes 
ProteomicsActivity-based SWATH/DIA proteomic screen enables sensitive differential detection of serine hydrolases from surgically resected OCT-embedded primary lung adenocarcinoma
Lung malignancies are among the leading causes of cancer-related death in the modern world. While the disease is relatively manageable if caught at an early stage, the genomic variability and high level of mutations represent a daunting challenge for diagnosis, staging and prognostic classification....
ORGANISM(S): Homo sapiens (Human) 
2025-06-02 | PXD019357 | Pride
Abpp Lung adenocarcinoma tissue Swath-ms 
GenomicsTranscriptomic profiling of the deletion of NUDIX hydrolases in Sulfolobus acidocaldarius
Transcriptomic profiling of the deletion of NUDIX hydrolases in Sulfolobus acidocaldarius
PRJEB60684 | ENA
ProteomicsMixed Alkyl/Aryl Phosphonates Identify Metabolic Serine Hydrolases as Antimalarial Targets
Malaria, caused by Plasmodium falciparum, remains a significant health burden. The barrier for developing anti-malarial drugs is the ability of the parasite to rapidly generate resistance. We previously demonstrated that Salinipostin A (SalA), a natural product, potently kills parasites by inhibitin...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum (isolate 3D7) 
2024-07-15 | PXD051499 | Pride
Plasmodium Lipid metabolism Serine hydrolases Activity-based probes 
ProteomicsArchaea produce peptidoglycan hydrolases that kill bacteria
The social life of archaea is poorly understood. In particular, even though competition and conflict are common themes in microbial communities, there is scant evidence documenting antagonistic interactions between archaea and their abundant prokaryotic brethren: bacteria. Do archaea specifically ta...
ORGANISM(S): Haloferax volcanii SB1 
2026-02-07 | PXD064732 | Pride
Archaea Peptidoglycan hydrolase 
ProteomicsActivity-Based Protein Profiling of Human and Plasmodium Serine Hydrolases and Interrogation of Potential Antimalarial Targets
Malaria remains a global health issue requiring the identification of novel therapeutic targets to combat drug resistance. Metabolic serine hydrolases are druggable enzymes playing essential roles in lipid metabolism. However, very few have been investigated in malaria-causing parasites. Here, we us...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum (isolate 3D7) 
2022-10-14 | PXD035891 | Pride
Abp Abpp Plasmodium falciparum Serine hydrolase Malaria Chemical proteomics Fluorophosphonate 
ProteomicsMetaproteomic analysis of the hydrolases
Multiple hydrolases excreted by the enriched CSDC were requisite for the hydrolysis of CS
ORGANISM(S): Environmental Samples <ascomycetes,capnodiales Incertae Sedis> 
PXD068265 |
UnknownComputational design of serine hydrolases.
Not available
S-EPMC11384011 | biostudies-literature
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