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ProteomicsCancer-associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC
The FBXW7 tumour suppressor is commonly mutated, deleted or hypermethylated in a variety of cancer histologies. The tumour suppressive role of the FBXW7 protein has been ascribed to its ability to drive the ubiquitination and degradation of oncoproteins via its role as a substrate recognition subuni...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD043904 | Pride
Cdc Fbxw7 Synthetic lethal 
UnknownCorrelation of changes in inflammatory and collagen biomarkers with durable guselkumab efficacy through 2 years in participants with active psoriatic arthritis: results from a phase III randomized controlled trial.
Not available
S-EPMC11528637 | biostudies-literature
ProteomicsPPP2R1A mutations cause ATR inhibitor synthetic lethality in ARID1A deficient ovarian clear cell carcinoma
Ovarian clear cell carcinoma (OCCC) is a cancer of unmet need characterized by ARID1A mutation. Prior work identified an ARID1A/ATR synthetic lethality, information that led to phase II clinical trials. Using genome-wide CRISPR-Cas9 mutagenesis and interference screens, we identified protein phospha...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD040422 | Pride
Atr Arid1a Ovarian clear cell carcinoma Synthetic lethality 
ProteomicsInhibition of GPX4 enhances CDK4/6 inhibitor activity in breast cancer.
CDK4/6 inhibition is the standard of care for estrogen receptor positive (ER+) breast cancer, although cytostasis is frequently observed, and new treatment strategies that enhance efficacy are required. We performed a genome-wide CRISPR screen to identify genetic determinants of CDK4/6 inhibitors se...
ORGANISM(S): Homo sapiens (Human) 
2023-06-20 | PXD043133 | Pride
Breast cancer Gpx4 Cdk4/6 inhibitor 
TranscriptomicsIn utero exposure to arsenic via drinking water impairs lung development and mucociliary clearance genes.
In utero exposure to arsenic via drinking water increases the risk of lower respiratory tract infections during infancy and mortality from bronchiectasis in adulthood. Pregnant mice were exposed to arsenic, and gene expression patterns were profiled in peripheral lung tissue obtained from the offspr...
ORGANISM(S): Mus musculus 
2013-06-04 | E-GEOD-37831 | biostudies-arrayexpress
ProteomicsTargeting the CDS1/2 axis as a therapeutic strategy in uveal melanoma and pan-cancer
Metastatic uveal melanoma is an aggressive disease with limited effective therapeutic options. To comprehensively map monogenic and digenic dependencies, we performed CRISPR-Cas9 screening in ten extensively profiled human uveal melanoma cell line models using genome-wide single gene/gRNA and combin...
ORGANISM(S): Homo sapiens (Human) 
2025-04-01 | PXD053752 | Pride
Cds1 Cds2 Uveal melanom 
GenomicsEGAS00001000055-sc-20120125 - samples
Analysis of genomic integrity of disease-corrected human induced pluripotent stem cells by exome sequencing
EGAD00001000086 | EGA
GenomicsEGAS00001000055-sc-20110804 - samples
Analysis of genomic integrity of disease-corrected human induced pluripotent stem cells by exome sequencing
EGAD00001000030 | EGA
GenomicsAnalysis of genomic integrity of disease corrected human induced pluripotent stem cells by exome sequencing
Induced pluripotent stem (iPS) cells hold great promise for autologous cell transplantation. In order to apply this therapy to monogenic disorder, disease-causing mutations must be corrected prior to transplantation. We generated iPS cells from patients with alpha-1 antitrypsin deficiency, which is ...
EGAS00001000055 | EGA
GenomicsDAC for study SEQCAP Analysis Of Genomic Integrity Of Disease Corrected Human Pluripotent Stem Cells
Data Access Committee EGAC00001000021
EGAC00001000021 | EGA
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