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ProteomicsA Novel QconCAT-Based Proteomics Method for Determining Allele-Specific Protein Expression (ASPE)
In the present study, we developed a novel targeted proteomics approach for quantification of allele-specific protein expression (ASPE) based on scheduled high resolution multiple reaction monitoring (sMRM-HR) with a heavy stable isotope-labeled quantitative concatamer (QconCAT) internal protein sta...
ORGANISM(S): Homo sapiens (Human) 
2018-08-28 | PXD008788 | Pride
Human Allele-specific protein expression Liver 
MetabolomicsThe Bardet-Biedl protein Bbs1 controls photoreceptor outer segment protein and lipid composition

Summary

Primary cilia are key sensory organelles whose dysfunction leads to ciliopathy disorders such as Bardet-Biedl syndrome (BBS). Retinal degeneration is common in ciliopathies, since the outer segments (OSs) of photoreceptors are highly specialized primary cilia. BBS...

2022-02-18 | MTBLS4013 | MetaboLights
TranscriptomicsAllele-specific Methylation of Human Placental Tissue
In this study, we screened human placental samples for allele-specific methylation and subsequently novel imprinted genes associated with these regions. We used reduced representation bisulfite sequencing to identify partially methylated CpG islands (CGIs) in the human placental genome. We were able...
ORGANISM(S): Homo sapiens 
2013-10-09 | E-GEOD-40955 | biostudies-arrayexpress
GenomicsPowerful Identification of Cis-regulatory SNPs in Human Primary Monocytes Using Allele-Specific Gene Expression
The aim of this study was to compare the power to detect associations between SNPs using cis-eQTL mapping and ASE analysis (allele specific expression).
EGAS00000000119 | EGA
ProteomicsPolysomal profiling coupled to allele-specific proteomics reveals an EIF4H tranSNP allele possessing higher mRNA translation potential
To search for genetic sources of allele-specific mRNA translation, we leveraged heterozygous polymorphisms and variants present in the exome of HCT116-derived cell lines, computing allelic fractions in total and polysome-associated RNA from RNA-seq data. Allelic imbalance in polysomal RNA led us to ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-16 | PXD063767 | Pride
Snps Allele-specific proteomics Allelic imbalance Mrna translation Eif4h 
ProteomicsDessert banana vs plantain: characterization of allele specific protein isoforms that are correlated to the fruit maturation process
Dessert bananas have a soft texture and sweet taste at maturity. Plantain fruits belongs to Musa spp (AAB) and are known cooking bananas. This popular name is due to the fact that these fruits do keep a high amount of starch even after complete maturation and have a different flesh texture being not...
ORGANISM(S): Musa 
2018-01-22 | PXD005589 | Pride
Banana breeding Plantain Proteomic Allele specific Banana 
TranscriptomicsAllele-specific expression and eQTL analysis in mouse adipose tissue
In this study we use RNAseq to explore allele specific expression (ASE) in adipose tissue of male and female F1 mice, produced from reciprocal crosses of C57BL/6J and DBA/2J strains. Comparison of the identified cis-eQTLs, to local-eQTLs, that were obtained from adipose tissue expression in two prev...
ORGANISM(S): Mus musculus 
2014-06-05 | E-GEOD-58239 | biostudies-arrayexpress
TranscriptomicsAllele specific expression in Arabidopsis thaliana Col-0 x Van-0 F1 hybrids
This SuperSeries is composed of the following subset Series: GSE16503: Genomic DNA concentration series in Allele Specific Expression study GSE16504: Genomic DNA mixture series in Allele Specific Expression study GSE16505: Genomic DNA 1:1 mixtures in Allele Specific Expression study GSE16506: mRNA s...
ORGANISM(S): Arabidopsis thaliana 
2009-08-15 | E-GEOD-16520 | biostudies-arrayexpress
ProteomicsPolysomal profiling coupled to allele-specific proteomics reveals an EIF4H tranSNP allele possessing higher mRNA translation potential
To search for genetic sources of allele-specific mRNA translation, we leveraged heterozygous polymorphisms and variants present in the exome of HCT116-derived cell lines, computing allelic fractions in total and polysome-associated RNA from RNA-seq data. Allelic imbalance in polysomal RNA led us to ...
ORGANISM(S): Homo Sapiens 
PXD073180 | panorama
TranscriptomicsDynamics of gene silencing during X inactivation using allele-specific RNA-Seq
Background: During early embryonic development, one of the two X chromosomes in mammalian female cells is inactivated to compensate for a potential imbalance in transcript levels with male cells containing a single X chromosome. We use mouse female Embryonic Stem Cells (ESCs) with nonrandom XCI and ...
ORGANISM(S): Mus musculus 
2015-06-15 | E-GEOD-60738 | biostudies-arrayexpress
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